Regulation of Transcriptional Bursting and Spatial Patterning in Early

César Nieto, Zahra Vahdat, Bomyi Lim, Abhyudai Singh

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

César NietoDepartment of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA.ORCID 0000-0001-6504-4619

Zahra VahdatDepartment of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA.ORCID 0000-0001-9794-5147

Bomyi LimDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3058-9181

Abhyudai SinghDepartment of Electrical and Computer Engineering, Biomedical Engineering, Mathematical Sciences, Center of Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA.ORCID 0000-0002-1451-2838

Funding

Design principles and dynamic gene control in embryonic developmentR35GM133425 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Bomyi Lim · 2019 to 2026

$2.9M

Generalized fluctuation test for deciphering phenotypic switching within cell populationsR35GM148351 · NIGMS · UNIVERSITY OF DELAWARE · PI Abhyudai Singh · 2023 to 2026

$1.6M

NIGMS NIH HHS R35 GM133425NIGMS NIH HHS R35 GM148351

6 · The paper itself

Abstract

Nascent RNA synthesis often occurs in periods of high transcriptional activity, interspersed with basal or no activity periods. This phenomenon, known as transcriptional bursting, drives high intercellular variability in gene expression levels. How do key patterning genes in early

Identifiers

PMID40654818

DOI10.1101/2025.05.02.651973

PMCPMC12248051

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.