Evidence map›Paper›PMID 40654795›Full record

ArticlebioRxiv : the preprint server for biology2025

PBDE flame retardant exposure causes neurobehavioral and transcriptional effects in first-generation but not second-generation offspring fish.

Nicole McNabb-Kelada, Tara Burke, Saro Jayaraman, Lesley Mills, Ashley De La Torre, Madison Francoeur, Hannah Schrader, Diane Nacci, Bryan Clark, Andrew Whitehead

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Nicole McNabb-KeladaDepartment of Environmental Toxicology, University of California Davis, Davis, CA 95616, USA.
Tara BurkeAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, RI 02882, USA.
Saro JayaramanAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, RI 02882, USA.
Lesley MillsAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, RI 02882, USA.
Ashley De La TorreDepartment of Environmental Toxicology, University of California Davis, Davis, CA 95616, USA.
Madison FrancoeurAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, RI 02882, USA.
Hannah SchraderAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, RI 02882, USA.
Diane NacciAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, RI 02882, USA.
Bryan ClarkAtlantic Coastal Environmental Sciences Division, US EPA Office of Research and Development, Narragansett, RI 02882, USA.
Andrew WhiteheadDepartment of Environmental Toxicology, University of California Davis, Davis, CA 95616, USA.

Funding

ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
NIEHS NIH HHS T32 ES007059
6 · The paper itself

Abstract

Environmental pollutants can have lasting effects that extend beyond the exposure period, potentially impacting multiple generations. Despite the widespread presence of polybrominated diphenyl ether (PBDE) flame retardants in the environment including oceans globally, there is limited understanding of their potential for multigenerational toxicity. We investigated whether exposures to 2,2',4,4',5-pentaBDE (BDE-99), a predominant PBDE congener, can induce neurobehavioral and molecular effects across two generations using the marine vertebrate model fish

Identifiers

PMID40654795
PMCPMC12247704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.