Evidence map›Paper›PMID 40654782›Full record

ArticlebioRxiv : the preprint server for biology2025

Astrocyte-derived PTPRZ1 regulates astrocyte morphology and excitatory synaptogenesis.

Alex R Eaker, Hayli E Spence-Osorio, Katherine T Baldwin

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Alex R EakerNeuroscience Center, University of North Carolina, Chapel Hill, USA.
Hayli E Spence-OsorioNeuroscience Center, University of North Carolina, Chapel Hill, USA.
Katherine T BaldwinNeuroscience Center, University of North Carolina, Chapel Hill, USA.ORCID 0000-0002-4423-5712

Funding

RESEARCH TRAINING IN THE NEUROSCIENCEST32NS007431 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juan Song, Mark J. Zylka · 1997 to 2026
$10.0M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
The facts of the matter: decoding the molecular properties of brain white matter using cell-type-specific quantitative proteomicsDP2NS136873 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Katherine Therese Baldwin · 2023 to 2026
$2.3M
NICHD NIH HHS P50 HD103573NINDS NIH HHS DP2 NS136873NINDS NIH HHS T32 NS007431
6 · The paper itself

Abstract

Protein tyrosine phosphatase receptor type Z1 (PTPRZ1) is one of the most abundantly expressed and enriched proteins in astrocytes during development, yet its function in astrocytes is unknown. Using an astrocyte-neuron co-culture system, we found that knockdown of

Indexed as

astrocytedevelopmentmorphologysynapse

Identifiers

PMID40654782
PMCPMC12248130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.