Evidence map›Paper›PMID 40654771›Full record

ArticlebioRxiv : the preprint server for biology2025

Mycobacterial Phenolic Glycolipid Triggers ATP-Mediated Neuronal P2X3 Signaling and Cough.

Kubra F Naqvi, Lois L Warden, J Hessel M van Dijk, Dhananjay K Naik, Felipe de Jesus Espinosa-Becerra, Ifunanya M Okolie, Vincent V F Verhoeks, Kathryn C Rahlwes, Christopher P Xavier, Jeroen D C Codee and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kubra F NaqviDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4703-9466
Lois L WardenDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7269-3243
J Hessel M van DijkBio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, RA-2300 Leiden, The Netherlands.
Dhananjay K NaikDepartment of Neuroscience, University of Texas at Dallas, Richardson, TX, USA.ORCID 0000-0002-6226-7339
Felipe de Jesus Espinosa-BecerraCenter for Advanced Pain Research, University of Texas at Dallas, Richardson, TX, USA.ORCID 0000-0002-6997-1310
Ifunanya M OkolieDepartment of Neuroscience, University of Texas at Dallas, Richardson, TX, USA.ORCID 0009-0006-5586-3825
Vincent V F VerhoeksBio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, RA-2300 Leiden, The Netherlands.ORCID 0009-0003-4144-0619
Kathryn C RahlwesDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8101-5604
Christopher P XavierDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0004-7563-4531
Jeroen D C CodeeBio-Organic Synthesis, Leiden Institute of Chemistry, Leiden University, RA-2300 Leiden, The Netherlands.ORCID 0000-0003-3531-2138
Theodore J PriceDepartment of Neuroscience, University of Texas at Dallas, Richardson, TX, USA.ORCID 0000-0002-6971-6221
Michael U ShilohDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4329-2253

Funding

Transmission Aerobiology of M. tuberculosis: Genes and Metabolic Pathways That Sustain Mtb Across an Evolutionary BottleneckP01AI159402 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI NATHAN, CARL FRANCIS, RHEE, KYU Y · 2021 to 2025
$15.8M
Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6M
MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
Mechanisms of cough in Mycobacterium tuberculosis transmissionR01AI158688 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SHILOH, MICHAEL · 2021 to 2025
$3.6M
NIAID NIH HHS P01 AI159402NIAID NIH HHS R01 AI158688NIAID NIH HHS T32 AI007520NINDS NIH HHS U19 NS130608
6 · The paper itself

Abstract

Cough drives respiratory pathogen transmission, yet how microbes directly engage host sensory neurons to trigger cough is largely unknown. We previously demonstrated that the

Identifiers

PMID40654771
PMCPMC12248122

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.