Evidence map›Paper›PMID 40654768›Full record

ArticlebioRxiv : the preprint server for biology2025

Neural signaling contributes to heart formation and growth in the invertebrate chordate,

Hannah N Gruner, C J Pickett, Jasmine Yimeng Bao, Richard Garcia, Akiko Hozumi, Tal Scully, Shaoyang Ning, Mavis Gao, Gia Bautista, Keren Maze and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Hannah N GrunerSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
C J PickettSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Jasmine Yimeng BaoSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Richard GarciaSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Akiko HozumiShimoda Marine Research Center, University of Tsukuba, 5-10-1, Shimoda, Shizuoka, 415-0025, Japan.
Tal ScullyHarvard Medical School, Warren Alpert Building Room 536, 200 Longwood Ave Boston, MA 2114, USA.
Shaoyang NingSwarthmore College, Statistics in the Department of Mathematics & Statistics at Swarthmore College, 500 College Ave, Swarthmore, PA 19081, USA.
Mavis GaoSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Gia BautistaSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Keren MazeSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Karissa LimSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Tomohiro OsugiThe Bioorganic Research Institute, Suntory Foundation for Life Sciences (SUNBOR), 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto, 619-0284, Japan.
Mae Collins-DoijodeSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Ofubofu CairnsSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Gabriel LevisSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Shu Yi ChenSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
TaiXi GongSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.
Honoo SatakeThe Bioorganic Research Institute, Suntory Foundation for Life Sciences (SUNBOR), 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto, 619-0284, Japan.
Allon Moshe-KleinHarvard Medical School, Warren Alpert Building Room 536, 200 Longwood Ave Boston, MA 2114, USA.
Eduardo D GiganteSchool of Biological Sciences, College of Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Yasunori SasakuraShimoda Marine Research Center, University of Tsukuba, 5-10-1, Shimoda, Shizuoka, 415-0025, Japan.
Bradley DavidsonSwarthmore College, Department of Biology, 500 College Ave, Swarthmore, PA 19081, USA.

Funding

Revealing the mechanisms of neural-mediated cardiac proliferation in Ciona robustaF32HL170997 · NHLBI · SWARTHMORE COLLEGE · PI GRUNER, HANNAH · 2023 to 2024
$160k
NHLBI NIH HHS F32 HL170997
6 · The paper itself

Abstract

Neurons contribute to the complex interplay of signals that mediate heart development and homeostasis. Although a limited set of studies suggest that neuronal peptides impact vertebrate heart growth, the specific contributions of these peptides to cardiomyocyte progenitor differentiation or proliferation have not been elucidated. Here we show that the neuropeptide tachykinin along with canonical Wnt signaling regulate cardiomyocyte progenitor proliferation in the chordate model

Identifiers

PMID40654768
PMCPMC12247680

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.