Evidence map›Paper›PMID 40654766›Full record

ArticlebioRxiv : the preprint server for biology2025

Constitutive Androstane Receptor induces Ribonucleotide Reductase-M2 expression and maintains hepatocyte ploidy in mice.

Anjana Asokakumar, Bhoomika Mathur, Anthony Chau, Bea Cronologia, Frances Alencastro, Linda Wheeler, Christopher K Mathews, David D Moore, Andrew W Duncan, Sayeepriyadarshini Anakk

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anjana AsokakumarDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.ORCID 0009-0004-3821-5880
Bhoomika MathurDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0001-7146-1072
Anthony ChauDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
Bea CronologiaDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
Frances AlencastroDepartment of Pathology, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Linda WheelerDepartment of Biochemistry and Biophysics, Oregon State University, Oregon, USA.
Christopher K MathewsDepartment of Biochemistry and Biophysics, Oregon State University, Oregon, USA.
David D MooreNutritional Science and Toxicology, University of California, Berkeley, USA.ORCID 0000-0002-5151-9748
Andrew W DuncanDepartment of Pathology, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4962-4191
Sayeepriyadarshini AnakkDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.ORCID 0000-0003-2819-695X

Funding

Pittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shuchang Silvia Liu · 2019 to 2026
$10.9M
Mechanisms of Polyploidy and Aneuploidy in the LiverR01DK103645 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W · 2014 to 2023
$4.1M
Understanding Mechanisms that Regulate Liver Growth and FunctionR01DK113080 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Sayeepriyadarshini Anakk · 2017 to 2026
$3.3M
NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK103645NIDDK NIH HHS R01 DK113080
6 · The paper itself

Abstract

The nuclear receptor Constitutive Androstane Receptor (CAR/NR1i3) is known for regulating various liver functions, including detoxification, nutrient metabolism, and hepatocyte proliferation. While CAR activation has been previously linked to higher ploidy, the underlying mechanisms are not fully known. Here, we uncover a basal role for CAR in maintaining hepatocyte ploidy, such that CAR deletion increases the number of diploid (2c) hepatocytes with a concomitant reduction in tetraploid (4c) hepatocytes. We demonstrate that CAR controls the

Identifiers

PMID40654766
PMCPMC12247678

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.