Evidence map›Paper›PMID 40654755›Full record

ArticlebioRxiv : the preprint server for biology2025

Quantification of single cell-type-specific alternative transcript initiation.

Shuhua Fu, Parker Wilson, Bo Zhang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shuhua FuDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Parker WilsonDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Bo ZhangDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID 0000-0003-2962-5314

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
Transcriptional regulation of domesticated transposable elements-derived promoters in human genomeR35GM142917 · NIGMS · WASHINGTON UNIVERSITY · PI ZHANG, BO ABER · 2021 to 2025
$1.9M
NIDDK NIH HHS P30 DK019525NIGMS NIH HHS R35 GM142917
6 · The paper itself

Abstract

Cells can transcribe different isoforms of a gene by using distinct Transcriptional Start Regions (TSRs), which are recognized by RNA-Polymerase II and regulated by cell-type-specific expressed transcription factors, eventually forming tissue and cell-type-specific expression during development. However, how the distinct TSRs are selectively activated in different tissues and cell types remains largely uncharacterized. To better explore the alternative usage of gene TSRs, we developed

Indexed as

expression quantificationlong-read sequencingsingle-cell transcriptometranscription initiation

Identifiers

PMID40654755
PMCPMC12247766

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.