Evidence map›Paper›PMID 40654735›Full record

ArticlebioRxiv : the preprint server for biology2025

RNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient m

Brittany Shimanski, Juan F Marin, Marcin Warminski, Riley M McKeon, Joanna Kowalska, Jacek Jemielity, Jodi A Hadden-Perilla, Jeffrey S Mugridge

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Brittany ShimanskiDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, United States.
Juan F MarinDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, United States.
Marcin WarminskiDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland.
Riley M McKeonDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, United States.
Joanna KowalskaDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0002-9174-7999
Jacek JemielityCentre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland.ORCID 0000-0001-7633-788X
Jodi A Hadden-PerillaDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, United States.ORCID 0000-0003-4685-8291
Jeffrey S MugridgeDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, United States.ORCID 0000-0002-1553-3008

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Selectivity and regulation of mRNA demethylation by iron-dependent dioxygenasesR35GM143000 · NIGMS · UNIVERSITY OF DELAWARE · PI MUGRIDGE, JEFFREY SCOTT · 2021 to 2025
$2.1M
Data Management and Storage System for Shared Resource FacilitiesS10OD028725 · OD · UNIVERSITY OF DELAWARE · PI POLSON, SHAWN W · 2021 to 2021
$600k
NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS R35 GM143000NIGMS NIH HHS T32 GM133395NIH HHS S10 OD028725
6 · The paper itself

Abstract

The RNA demethylase FTO acts as a methyl 'eraser' to remove either internal

Identifiers

PMID40654735
PMCPMC12248013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.