Evidence map›Paper›PMID 40654734›Full record

ArticlebioRxiv : the preprint server for biology2025

The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.

Elizabeth S Kitto, Shijiao Huang, Mira Bhandari, Cassie Tian, Rebecca L Cox, Safa Beydoun, Emily Wang, Danielle Shave, Hillary A Miller, Sarah A Easow and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elizabeth S KittoMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.ORCID 0000-0003-3414-1509
Shijiao HuangDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, United States.ORCID 0000-0003-1867-4794
Mira BhandariMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.ORCID 0009-0006-4143-2522
Cassie TianMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.ORCID 0009-0003-7673-7295
Rebecca L CoxMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.ORCID 0000-0002-6251-087X
Safa BeydounMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.ORCID 0000-0001-8068-3953
Emily WangDepartment of Cellular and Developmental Biology; University of Michigan, Ann Arbor, United States.
Danielle ShaveMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.
Hillary A MillerCellular and Molecular Biology Program, University of Michigan, Ann Arbor, United States.
Sarah A EasowMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.ORCID 0000-0002-0849-8363
Ella HenryMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.
Megan L SchallerMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.
Scott F LeiserMolecular and Integrative Physiology Department; University of Michigan, Ann Arbor, United States.ORCID 0000-0002-8003-2955

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
Research Training in BiogerontologyT32AG000114 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 1985 to 2026
$12.4M
Mechanisms of cell non-autonomous signaling through the hypoxic responseR01AG058717 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEISER, SCOTT F · 2019 to 2023
$1.6M
Determining the neural mechanisms of mechanosensory food perception in DR-mediated longevityF31AG084146 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KITTO, ELIZABETH SARAH · 2023 to 2024
$83k
NIA NIH HHS F31 AG084146NIA NIH HHS P30 AG024824NIA NIH HHS R01 AG058717NIA NIH HHS T32 AG000114
6 · The paper itself

Abstract

A coordinated response to stress is crucial for promoting the short- and long-term health of an organism. The perception of stress, frequently through the nervous system, can lead to physiological changes that are fundamental to maintaining homeostasis. Activating the response to low oxygen, or hypoxia, extends healthspan and lifespan in

Identifiers

PMID40654734
PMCPMC12247763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.