ArticlebioRxiv : the preprint server for biology2025
Profiling Bile Acids in the Stools of Humans and Animal Models of Cystic Fibrosis.
Melissa M Carmichael, Rebecca A Valls, Shannon Soucy, Julie Sanville, Juliette Madan, Sarvesh V Surve, Mark S Sundrud, George A O'Toole
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Melissa M CarmichaelDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755.
Rebecca A VallsDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755.
Shannon SoucyDepartment of Biomedical Data Science, Geisel School of Medicine, Hanover, NH, 03755, USA.
Julie SanvilleDepartment of Pediatrics, Dartmouth Health, Lebanon, NH 03766.
Juliette MadanDepartment of Pediatrics, Dartmouth Health, Lebanon, NH 03766.
Sarvesh V SurveDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755.
Mark S SundrudDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755.ORCID 0000-0002-4249-0525 George A O'TooleDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755.ORCID 0000-0002-2861-4392 Funding
Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI MICHAEL L WHITFIELD · 2019 to 2026
$27.2MTranslational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEAN R MADDEN · 2018 to 2026
$13.9MHOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9MNuclear Receptor Control of T Cell Function in Discrete Intestinal MicroenvironmentsR01AI164772 · NIAID · UNIVERSITY OF FLORIDA · PI SUNDRUD, MARK SCOTT, WEAVER, CASEY T · 2021 to 2025
$4.5MNuclear Receptor Networks in Mucosal Immune RegulationU01AI163063 · NIAID · UNIVERSITY OF FLORIDA · PI PIPKIN, MATTHEW EUGENE, SUNDRUD, MARK SCOTT · 2021 to 2025
$2.2MDartmouth Cystic Fibrosis Training ProgramT32HL134598 · NHLBI · DARTMOUTH COLLEGE · PI George A. O'Toole · 2017 to 2026
$1.7MNATIONAL FERRET RESOURCE AND RESEARCH CENTER ON LUNG DISEASE75N92024C00008 · NHLBI · UNIVERSITY OF IOWA · PI BOYLE, JESSICA · 2024 to 2024
$1.7MArsenic, the Microbiome & Health Outcomes: Mechanisms to Methods of InterventionR01ES033988 · NIEHS · DARTMOUTH COLLEGE · PI George A. O'Toole · 2023 to 2026
$1.6MNHLBI NIH HHS 75N92024C00008NHLBI NIH HHS T32 HL134598NIAID NIH HHS R01 AI164772NIAID NIH HHS T32 AI007519NIAID NIH HHS U01 AI163063NIDDK NIH HHS P30 DK117469NIEHS NIH HHS R01 ES033988NIGMS NIH HHS P20 GM130454
6 · The paper itselfAbstract
Cystic fibrosis (CF) is associated with dysbiosis of the gut microbiome, alterations in intestinal mucus production, aberrant bile acid (BA) metabolism, fat malabsorption, and chronic inflammation. As little is known about BAs in CF, we performed both comprehensive and targeted BA profiling in stool of children with or without CF. Our results reveal that select BA species and metabolites are significantly different between children with CF (cwCF) and healthy controls. There is also a trend towards higher primary cBA and total BA levels for cwCF. Matched bacterial metagenomic analyses showed no change in alpha-diversity between groups in our small cohort, at odds with previous studies, whereas changes in relative abundance of
Indexed as
bile acidscystic fibrosisferrethumanmouse
Identifiers
PMID40654714
PMCPMC12248097
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