Evidence map›Paper›PMID 40654711›Full record

ArticlebioRxiv : the preprint server for biology2025

A ubiquitous spectrolaminar motif across independent studies, including Mackey et al.'s own data.

Alex James Major, Ahmed Abdaltawab, Jessica M Phillips, Tian Wang, Eric Kenji Lee, Maxwell J Lichtenfeld, Chandramouli Chandrasekaran, Yuri B Saalmann, Alexander Maier, Robert Desimone and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alex James MajorThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Ahmed AbdaltawabDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Jessica M PhillipsDepartment of Psychology, University of Wisconsin-Madison; Madison, WI 53706, USA.
Tian WangDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Eric Kenji LeeDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Maxwell J LichtenfeldDepartment of Psychology, Vanderbilt University, Nashville, TN, 37212, USA.
Chandramouli ChandrasekaranDepartment of Anatomy & Neurobiology, Boston University, Boston, MA 02215, USA.
Yuri B SaalmannDepartment of Psychology, University of Wisconsin-Madison; Madison, WI 53706, USA.
Alexander MaierDepartment of Psychology, Vanderbilt University, Nashville, TN, 37212, USA.
Robert DesimoneMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Earl K MillerThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
André M BastosDepartment of Psychology, Vanderbilt University, Nashville, TN, 37212, USA.
Diego Mendoza-HallidayDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Funding

Testing the Mechanisms, Layers, and Frequencies of Prediction Encoding and its ViolationR00MH116100 · NIMH · VANDERBILT UNIVERSITY · PI BASTOS, ANDRE MORAES · 2021 to 2023
$729k
NIMH NIH HHS R00 MH116100
6 · The paper itself

Abstract

Our study (Mendoza-Halliday et al., 2024) made two contributions: (1) discovery of a ubiquitous cortical motif and (2) a tool derived from it-the Frequency-based Layer Identification Procedure (FLIP and vFLIP). Mackey et al. critique the tool, questioning its advantage over classic current source density (CSD) analysis, and reason backwards to challenge the motif's ubiquity. In our rebuttal, we confirm the spectrolaminar motif in diverse cortical areas using data from multiple research groups (who joined us in this rebuttal) as well as Mackey et al.'s own dataset. Additionally, we introduce vFLIP2, an improved version of our tool that addresses their comments. It reliably identified and localized the motif in our data and Mackey et al.'s data. Our findings reaffirm the motif's ubiquity. We value Mackey et al.'s comments, which helped refine our tool.

Identifiers

PMID40654711
PMCPMC12247776

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.