Evidence map›Paper›PMID 40654660›Full record

ArticlebioRxiv : the preprint server for biology2025

RNA Helicase A promotes small RNA biogenesis and sorting in germ cells.

Olivia J Gaylord, Jordan S Brown, Wei-Sheng Wu, Heng-Chi Lee

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olivia J GaylordDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, 60637, USA.
Jordan S BrownDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, 60637, USA.
Wei-Sheng WuDepartment of Electrical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
Heng-Chi LeeDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, 60637, USA.

Funding

Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
piRNA-mediated genome surveillance of germline transcriptsR01GM132457 · NIGMS · UNIVERSITY OF CHICAGO · PI LEE, HENG-CHI · 2019 to 2023
$1.7M
NIGMS NIH HHS R01 GM132457NIGMS NIH HHS T32 GM007183NIH HHS P40 OD010440
6 · The paper itself

Abstract

In germ cells, small RNAs function as a defense system to silence invading RNAs like viruses and transposons to protect genome integrity. The ability of small RNAs to robustly silence diverse RNA sequences prompts the question of how endogenous mRNAs avoid this silencing. In

Identifiers

PMID40654660
PMCPMC12248108

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.