ArticlebioRxiv : the preprint server for biology2025
Abstinence from Substance Use & The Value of Control.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Clinical criteria for substance-use disorder collectively specify a loss of instrumental control over consumption, yet little empirical work has addressed how substance use shapes the utility of agency in motivated behavior. We combined a hierarchical gambling task with cross-sectional substance-use surveys and computational cognitive modeling, to assess the preference for controllable environments in adult humans with self-reported abstinence, across psychostimulant, opioid, alcohol, and sedative use. For psychostimulants, the duration of abstinence strongly modulated the preference for control, without affecting the ability to maximize monetary payoffs. In contrast, for alcohol, the recency of use was more predictive of a preference for environments with divergent outcome distributions, regardless of whether those outcomes were controllable. No effects of abstinence were seen for sedatives. The selective effects of psychostimulant use on the value of control implicate the dopaminergic system in agency coding.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.