ArticleFrontiers in allergy2025
Tropomyosin-based cross-reactivity and asymptomatic shellfish sensitization in patients with perennial allergy.
Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- The "Survivor Peptide" Hypothesis: Structural Resilience and Immunological Persistence of Food Allergens in the Gut-Mammary Axis.Nutrients · 2026Review
- Editorial: Allergen cross-reactivity - a challenge in daily practice.Frontiers in allergy · 2026Article
- A Detailed Characterization of Asthma Manifestations and Their Associations with Dietary Intakes in a Singapore Cohort of Young Chinese Adults: A Cross-Sectional Study.Journal of asthma and allergy · 2025Article
- IgE sensitization to house dust mite and cockroach allergens in asthmatic and allergic patients in the tropics.Frontiers in allergy · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Mite, cockroach, and shellfish (crab, clam, and shrimp) proteins share allergenic epitopes. The determination of specific IgE (sIgE) against cockroach ( Objective: This study aimed to evaluate whether cross-reactivity between aeroallergens and food allergens is clinically relevant and whether subjects with mite and/or cockroach sensitization are at risk of false-positive results in shellfish food allergy diagnostics. Methods: In this cross-sectional, single-center study, we recruited 200 patients with elevated sIgE against ≥1 allergen at random from our outpatient clinic and assessed allergic comorbidity. We analyzed sIgE against mites ( Results: During allergologic assessment, two participants reported previous anaphylaxis to fish and/or seafood and were excluded from further analysis. The final study population comprised 150 female and 48 male participants. Of these, 93 presented with positive sIgE against mites. As expected, participants with mite sensitization displayed an elevated prevalence of perennial asthma or allergic rhinitis ( Conclusion: Patients with mite sensitization have higher asymptomatic sIgE levels to shellfish. Even in patients with anti-tropomyosin sIgE levels below the cutoff level, anti-tropomyosin sIgE correlates strongly with sIgE against German cockroach, crab, clam, and shrimp. Our findings suggest large-scale false-positive results for sIgE to shellfish when analyzing patients with mite- or cockroach sensitization.
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