ArticleRegenerative therapy2025
Effects and the mechanism of pine pollen polysaccharides on diabetic wound healing
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Multifunctional Hydrogel Dressing Loaded with DH-EVs Promotes Healing of Bacteria-Infected Diabetic Wounds.Nanomaterials (Basel, Switzerland) · 2026Article
- Polysaccharides from the Peel ofPolymers · 2026Article
- Analysis of the Spatiotemporal Digestion Characteristics of Pine Pollen Processed by Different Methods in Middle-Aged Adults Using an In Vitro Digestion Model System.Foods (Basel, Switzerland) · 2026Article
- Study of the Cytotoxic and Wound Healing Activity of Polysaccharides fromMolecules (Basel, Switzerland) · 2026Article
- Neutrophil Extracellular Traps in Wound Healing of Diabetes: Mechanisms, Inducers, and Therapeutic Implications.Mediators of inflammation · 2026Review
- A Sponge-like Polysaccharide from Pine Pollen: Structural Features and Therapeutic Potential in DNCB-Induced Atopic Dermatitis Models.Pharmaceutics · 2025Article
- Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications ofFrontiers in pharmacology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Pine pollen polysaccharides (PPPS) has anti-inflammatory, immunomodulatory, anti-oxidant, hypoglycemic, and anti-bacterial properties. PPPS can accelerate wound healing in mouse cutaneous wounds, yet it is unclear whether PPPS can promote diabetic wound healing. Methods: Fibroblasts, keratinocytes, and human umbilical vein endothelial cells (HUVECs) were stimulated with high glucose (HG) to mimic hyperglycemic environment. Cell viability, apoptosis, migration, and angiogenesis were assessed by cell counting, Western blot, transwell migration, and tube formation assays. Neutrophil extracellular traps (NETs) and macrophage polarization were analyzed by immunofluorescence and flow cytometry. Streptozotocin-induced diabetes mellitus (DM) mice were subjected to skin wounds and PPPS administration to validate the role of PPPS in diabetic wound healing. Results: PPPS treatment impaired HG-induced viability reduction, apoptosis promotion, and migration repression of fibroblasts, keratinocytes, and HUVECs, accompanied by promotion of angiogenesis of HUVECs under HG stimulation. Specifically, PPPS treatment facilitated NET degradation and suppressed macrophage M1 polarization. Furthermore, PPPS accelerated diabetic wound healing in DM mice, along with decreased citrullinated H3 and PAD4 protein levels and elevated CD31 protein levels, suggesting that PPPS facilitated re-epithelialization and vascularization and reduced NETs. Conclusions: PPPS accelerates diabetic wound healing via mediating NETs and the polarization of M1-type macrophages, providing new insights into the promoting role of PPPS in diabetic wound healing.
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