ArticleJournal of dental sciences2025
Potential association between periodontitis and liver function test abnormalities: Results from the National Health and Nutrition Examination Survey (NHANES) 2009-2014.
Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Crosstalk between iron metabolism dysregulation and the oral microbiome in periodontitis.Journal of oral microbiology · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Previous studies have indicated that periodontitis was associated with various liver diseases; however, few large-scale population-level studies were available. This study aimed to conduct a comprehensive investigation into the associations between periodontitis and liver function test (LFT) indexes. Materials and methods: Data were sourced from 2009 to 2014 the National Health and Nutrition Examination Survey (NHANES) databases, and the study population included 10139 participants. LFTs included indicators of total protein (TP), albumin (ALB), globulin (GLB), alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (γ-GGT), and alkaline phosphatase (ALP). Propensity score matching (PSM) was used to increase the comparison. Multiple logistic regressions were used to examine the associations between periodontitis and LFT abnormalities in the total sample and age subgroups. Results: After PSM adjustments, logistic regression results indicated that periodontitis was significantly associated with an increased risk of TP (adjusted odds ratio (AOR) 1.46; 95 % confidence internal (CI): 1.02, 2.10), GLB (AOR 2.02; 95 % CI: 1.18, 3.45), γ-GGT (AOR 1.32; 95 % CI: 1.02, 1.70), and ALP (AOR 2.00; 95 % CI: 1.05, 3.84). In the subgroup aged 45-64 years, there was elevated odds of ALT levels (AOR 1.73; 95 % CI: 1.03, 2.9); in the subgroup aged 65 years or above, we identified a statistically significant association in ALP (AOR 5.39; 95 % CI: 1.62, 17.99). Conclusion: Periodontitis is associated with abnormal LFTs. Particularly, periodontitis may increase risks for elevated γ-GGT, ALP, and GLB levels. Furthermore, the relationship between periodontitis and LFTs showed significant heterogeneity across different age groups.
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