ArticleJournal of dental sciences2025
Potential short-term shift in oral microbiota of patients with stage III-IV periodontitis and type 2 diabetes treated by non-surgical periodontal therapy.
Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Association between dental flossing frequency and oral microbiome in U.S. adults.Annals of medicine · 2026Article
- Subgingival Microbiota Shifts Following Diode Laser-Activated Indocyanine Green Treatment in Periodontitis: A Pilot 16S rDNA Study.Microorganisms · 2026Article
- From health to periodontitis: dynamic changes in the subgingival microbiome and their association with systemic inflammation levels.Frontiers in cellular and infection microbiology · 2026Article
- Reframing glucolipid metabolic disorders through the lens of the oral microbiome: from pathophysiological mechanisms to translational potential.Frontiers in nutrition · 2026Review
- Severe periodontitis patients with well-controlled type 2 diabetes display a distinct subgingival microbiome with increased Saccharibacteria compared to systemically healthy controls.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Adjunctive use of systemic antibiotics has more clinical improvement than scaling and root planing alone in stage III-IV periodontitis patients with type 2 diabetes mellitus (T2DM). There is still no study that concentrate on dynamic changes in oral microbiota by high throughput sequencing technique with the treatment regimen including adjunctive antibiotics. Materials and methods: Thirty-two periodontitis patients with T2DM who received non-surgical periodontal treatment (NSPT) in the previously published randomized trial were selected for microbiological analysis. Seventeen subjects in the test group received scaling and root planing (SRP) and antibiotics (500 mg of amoxicillin [AMX], and 200 mg of metronidazole [MTZ], three times daily for seven days). Fifteen subjects in the control group received SRP only. Examination of periodontal and hematological parameters, cytokines in serum and gingival crevicular fluid, and collection of subgingival plaque was taken at baseline and three months after treatment. The V3-V4 region of 16S DNA was sequenced, and taxonomic assignment was based on the Human Oral Microbiome database. Results: Both the test and the control group showed lower richness and diversity for subgingival microbiota after treatment. The distribution of subgingival microbial composition was different between the baseline and 3 months in both groups. The subgingival microbial dysbiosis index decreased significantly in both groups at 3 months, and 8 out of 12 dysbiotic discriminatory genera decreased significantly in the test group. The relative abundance of the red complex, Conclusion: NSPT could significantly change the oral microbiome towards healthy status in patients with stage III-IV periodontitis and diabetes. AMX + MTZ had more advantages in the decrease of periodontal pathogens. Periodontists should cautiously use the antibiotics to treat such patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.