Evidence map›Paper›PMID 40654360›Full record

ArticleActa pharmaceutica Sinica. B2025

RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis.

Wen Zhang, Yulin Peng, Meirong Zhou, Lei Qian, Yilin Che, Junlin Chen, Wenhao Zhang, Chengjian He, Minghang Qi, Xiaohong Shu and 8 more

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Wen ZhangSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Yulin PengDalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian 116044, China.
Meirong ZhouSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Lei QianAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China.
Yilin CheSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Junlin ChenSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Wenhao ZhangSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Chengjian HeSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Minghang QiCollege of Pharmacy, Dalian Medical University, Dalian 116044, China.
Xiaohong ShuCollege of Pharmacy, Dalian Medical University, Dalian 116044, China.
Manman TianSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Xiangge TianSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Yan TianCollege of Pharmacy, Dalian Medical University, Dalian 116044, China.
Sa DengCollege of Pharmacy, Dalian Medical University, Dalian 116044, China.
Yan WangDalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian 116044, China.
Xiaokui HuoSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.
Zhenlong YuCollege of Pharmacy, Dalian Medical University, Dalian 116044, China.
Xiaochi MaSecond Affiliated Hospital, Dalian Medical University, Dalian 116000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis serves as an indicator of malignancy and is a biological characteristic of carcinomas. Epithelial-mesenchymal transition (EMT) plays a key role in the promotion of tumor invasion and metastasis and in the enhancement of tumor cell aggressiveness. Prostaglandin E synthase 3 (p23) is a cochaperone for heat shock protein 90 (HSP90). Our previous study showed that p23 is an HSP90-independent transcription factor in cancer-associated inflammation. The effect and mechanism of action of p23 on lung cancer metastasis are tested in this study. By utilizing cell models

Indexed as

CXCL1Epithelial–mesenchymal transitionInvasion and metastasisLung cancerProstaglandin E synthase 3Protein–protein interactionRNA-binding motif protein 14Transcriptional regulation

Identifiers

PMID40654360
PMCPMC12254758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.