Evidence map›Paper›PMID 40654327›Full record

ArticleFuture oncology (London, England)2025

Real-world post-2020 first-line maintenance treatment patterns in patients with advanced ovarian cancer in the US.

Dana M Chase, Linda Kalilani, Maureen A Cooney, Zsofia Kiss, Amanda K Golembesky, Monica Kobayashi, Megha Dayma, Elif Coskuncay, Jeanne M Schilder

Abstract read
In one paragraph

Article in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dana M ChaseDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-1073-8688
Linda KalilaniGSK, Durham, NC, USA.
Maureen A CooneyGSK, Durham, NC, USA.
Zsofia KissGSK, Munich, Germany.ORCID 0000-0002-8395-1949
Amanda K GolembeskyGSK, Durham, NC, USA.
Monica KobayashiGSK, Durham, NC, USA.
Megha DaymaGSK, Bengaluru, India.
Elif CoskuncayGSK, London, UK.ORCID 0009-0003-5151-4861
Jeanne M SchilderGSK, Philadelphia, PA, USA.ORCID 0000-0002-6322-5376

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo describe first-line maintenance (1LM) treatment patterns since 1 January 2020, for real-world patients with newly diagnosed advanced ovarian cancer (aOC). PATIENTS &

methodsThis retrospective study used a US-nationwide electronic health record-derived deidentified database. Eligible patients were aged ≥ 18 years with stage III/IV epithelial OC and initiated first-line platinum-based chemotherapy±bevacizumab (index; 01Jan2020-28Feb2023). Baseline characteristics and 1LM treatment patterns were summarized overall and by

resultsAmong 599 eligible patients (median [interquartile range] age, 67 [59-74] years; 59.8% White; 50.3% stage III disease), 15.5% had

conclusionsFewer than half of included patients with aOC received 1LM treatment in the real-world setting. More work is needed to understand reasons underlying real-world 1LM treatment choice for patients with aOC.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Ovarian EpithelialMaintenance ChemotherapyOvarian NeoplasmsAgedBevacizumabBRCA1 ProteinBRCA2 ProteinFemaleHumansMiddle AgedMutationNeoplasm StagingPoly(ADP-ribose) Polymerase InhibitorsRetrospective StudiesTreatment OutcomeBevacizumabBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinPoly(ADP-ribose) Polymerase Inhibitorsbevacizumabepithelial ovarian cancerfirst-line maintenancePARP inhibitorreal-world

Identifiers

PMID40654327
PMCPMC12330229

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.