Evidence map›Paper›PMID 40654319›Full record

ArticleJMIR formative research2025

Bringing Executive Function Testing Online: Assessment Validation Study.

Mouna Attarha, Ana Carolina de Figueiredo Pelegrino, Lydia Ouellet, Sarah-Jane Grant, Etienne de Villers-Sidani, Thomas Van Vleet

Registry-linked trialAbstract readValidation Study
In one paragraph

Article in JMIR formative research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04149457 (Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04149457 nacompletednot on this map

Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise (INHANCE)

TypeinterventionalSponsorPosit Science CorporationRan2021 to 2024Enrolled93ConditionsHealthy AgingArmsComputerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mouna AttarhaPosit Science Corporation, 160 Pine St Suite 200, San Francisco, CA, 94111, United States, 1 415-394-3100 ext 505.ORCID 0000-0003-3020-3768
Ana Carolina de Figueiredo PelegrinoMontreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0002-7220-5625
Lydia OuelletMontreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0003-1070-3597
Sarah-Jane GrantPosit Science Corporation, 160 Pine St Suite 200, San Francisco, CA, 94111, United States, 1 415-394-3100 ext 505.ORCID 0009-0000-4005-7421
Etienne de Villers-SidaniMontreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0003-1446-3295
Thomas Van VleetPosit Science Corporation, 160 Pine St Suite 200, San Francisco, CA, 94111, United States, 1 415-394-3100 ext 505.ORCID 0000-0003-1639-860X

Funding

Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE)R44AG039965 · NIA · POSIT SCIENCE CORPORATION · PI ATTARHA, MOUNA · 2014 to 2022
$2.4M
NIA NIH HHS R44 AG039965
6 · The paper itself

Abstract

Background: Executive function encompasses a set of higher-order cognitive processes, including planning, cognitive flexibility, and inhibitory control, that are essential for goal-directed behavior. These abilities are adversely affected by age, with executive dysfunction ultimately impairing the performance of activities of daily living. Objective: This study aimed to assess the validity of a computerized cognitive assessment in predicting executive function performance in healthy older adults. Methods: This retrospective analysis utilized baseline data from the Improving Neurological Health in Aging via Neuroplasticity-Based Computerized Exercise (INHANCE) trial. The study provides normative data for cognitively healthy older adults (aged 65 years and above) and evaluates the usability and validity of Freeze Frame, a cognitive assessment available on the BrainHQ platform. Performance on Freeze Frame was analyzed in relation to self-reported demographic variables and neuropsychological function, using a standardized measure of executive function, the National Institutes of Health Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and Research (NIH EXAMINER). Results: The intent-to-treat analysis included 92 cognitively healthy older adults (mean age 71.9, SD 4.86, range: 65-83 years), of whom 66% (61/92) were female, with a mean education level of 16.45 (SD 3.40, range: 9-27) years. Performance on Freeze Frame was modestly associated with executive function scores on NIH EXAMINER (P=.02), accounting for 6.8% of the variance. The assessment showed a small but statistically significant relationship to age (ρ=-0.22, P=.046) and gender, with no significant influence of education. Psychometric evaluation supported its usability, with an average completion time of 4 (SD 0.16) minutes. Conclusions: Freeze Frame is a brief, scalable, and accessible computerized cognitive assessment with demonstrated concurrent validity for executive function. Its efficiency and ease of administration across internet-connected devices suggests potential applications for cognitive screening. Future research should explore its utility in detecting executive dysfunction in clinical populations and its potential role in predicting functional performance across activities of daily living.

Indexed as

Executive FunctionNeuropsychological TestsActivities of Daily LivingAgedAged, 80 and overFemaleHumansMalePsychometricsReproducibility of ResultsRetrospective Studiesassessment accessibilitybrain healthcognitive statusexecutive functionNational Institutes of Health Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and ResearchNIH EXAMINERweb-based cognitive assessment

Identifiers

PMID40654319
PMCPMC12278174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.