Evidence map›Paper›PMID 40654268›Full record

ArticleEuropean journal of heart failure2025

Immune dysregulation as a key driver of peripartum cardiomyopathy - an exploratory advanced imaging and biomarker study.

Julian Hoevelmann, Charle Viljoen, Tessa Kotze, Carlos Libhaber, Stephen Jermy, Morné Kahts, Fareda Jakoet-Bassier, Petronella Samuels, Olivia Briton, Lynette Cilliers and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Cardiovascular imaging with total-body PET.The British journal of radiology · 2026
    Review
  2. From bump to pump: extracellular matrix remodeling, dynamics, and biomechanics in the maternal heart.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Julian HoevelmannCape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-2023-3026
Charle ViljoenCape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0001-7246-4136
Tessa KotzeCape Universities Body Imaging Centre, University of Cape Town, Cape Town, South Africa.
Carlos LibhaberSchool of Physiology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Stephen JermyCape Universities Body Imaging Centre, University of Cape Town, Cape Town, South Africa.
Morné KahtsDepartment of Medicine, Groote Schuur Hospital, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Fareda Jakoet-BassierCape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Petronella SamuelsCape Universities Body Imaging Centre, University of Cape Town, Cape Town, South Africa.
Olivia BritonCape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Lynette CilliersDepartment of Dietetics, Groote Schuur Hospital, Cape Town, South Africa.
Denise Hilfiker-KleinerInstitute Cardiovascular Complications in Pregnancy and Oncologic Therapies, Philipps University Marburg, Marburg, Germany.
Peter van der MeerDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Michael BöhmDepartment of Internal Medicine III - Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Saarland University, Homburg, Germany.
Ntobeko A B NtusiCape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Karen SliwaCape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-8272-0911

Funding

Deutsche Stiftung fr Herzforschung F/31/21
6 · The paper itself

Abstract

aimsPeripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy occurring in women in the late stages of pregnancy or in the postpartum period and is associated with significant morbidity, mortality, and persistent left ventricular dysfunction. PPCM pathogenesis involves multiple putative mechanisms including inflammation. We aimed to explore the acute inflammatory processes in PPCM using METHODS AND

resultsWomen with a new diagnosis of PPCM (n = 10, all within 3 months postpartum), five healthy postpartum controls (HPC), and five healthy non-postpartum controls (HNPC), underwent

conclusionsPatients with PPCM exhibited a dysregulated immune response, associated with early myocardial interstitial fibrosis and adverse cardiac remodelling. This highlights the importance of rapid initiation of guideline-directed medical therapy especially with drugs documented to have anti-fibrotic effects.

Indexed as

CardiomyopathiesPregnancy Complications, CardiovascularPuerperal DisordersAdultBiomarkersFemaleFluorodeoxyglucose F18HumansMagnetic Resonance Imaging, CinePeripartum CardiomyopathyPeripartum PeriodPositron Emission Tomography Computed TomographyPregnancyStroke VolumeVentricular Function, LeftBiomarkersFluorodeoxyglucose F18Cardiovascular magnetic resonanceImmune responsePeripartum cardiomyopathyPositron emission tomography

Identifiers

PMID40654268
PMCPMC12575422

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.