Evidence map›Paper›PMID 40654267›Full record

ArticleEuropean journal of immunology2025

AK2-Deficient Mice Recapitulate Impaired Lymphopoiesis of Reticular Dysgenesis Patients, but Also Lack Erythropoiesis.

Rebekka Waldmann, Franziska Werner, Alpaslan Tasdogan, Felix Immanuel Maier, Ursula Kohlhofer, Irene Gonzalez-Menendez, Leticia Quintanilla de Fend, Amrit Kaur Puarr, Ruth Maree Arkell, Anselm Enders and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rebekka WaldmannInstitute For Transfusion Medicine, Ulm University, Ulm, Germany.
Franziska WernerInstitute of Immunology, University Hospital, Ulm, Germany.
Alpaslan TasdoganInstitute of Immunology, University Hospital, Ulm, Germany.
Felix Immanuel MaierDivision of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Ursula KohlhoferInstitute of Pathology and Neuropathology and Comprehensive Cancer Center Tuebingen, Eberhard-Karls-University, Tuebingen, Germany.
Irene Gonzalez-MenendezInstitute of Pathology and Neuropathology and Comprehensive Cancer Center Tuebingen, Eberhard-Karls-University, Tuebingen, Germany.
Leticia Quintanilla de FendInstitute of Pathology and Neuropathology and Comprehensive Cancer Center Tuebingen, Eberhard-Karls-University, Tuebingen, Germany.
Amrit Kaur PuarrMaternal and Foetal Precision Health, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Ruth Maree ArkellMaternal and Foetal Precision Health, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Anselm EndersDivision of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Manfred HoenigDepartment of Pediatrics, Universal Medical Center Ulm, Ulm, Germany.
Hubert SchrezenmeierInstitute For Transfusion Medicine, Ulm University, Ulm, Germany.
Hans Joerg FehlingInstitute of Immunology, University Hospital, Ulm, Germany.
Klaus SchwarzInstitute For Transfusion Medicine, Ulm University, Ulm, Germany.
Ulrich PannickeInstitute For Transfusion Medicine, Ulm University, Ulm, Germany.

Funding

Fritz Thyssen Stiftung Az. 10.13.2.190
6 · The paper itself

Abstract

Reticular dysgenesis (RD) is a rare genetic disorder caused by mutations in the adenylate kinase 2 (AK2) gene. It is characterized by a T

Indexed as

Adenylate KinaseErythropoiesisLymphopoiesisSevere Combined ImmunodeficiencyAnimalsDisease Models, AnimalHumansLeukopeniaMiceMice, KnockoutThymus GlandAdenylate Kinaseadenylate kinase 2AK2‐deficient mouse modelimpaired lymphopoiesisreticular dysgenesissevere anaemia

Identifiers

PMID40654267
PMCPMC12257577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.