ArticleDiabetes, obesity & metabolism2025
Changes in adiposity indices over 10 years and risk of type 2 diabetes: The Whitehall II cohort study.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Baseline and longitudinal joint associations of alcohol consumption and obesity with diabetes risk: evaluating multiplicative and additive interactions.Diabetologia · 2026Article
- Beyond Single Anthropometric Measures: Integrating Waist Circumference and Body Mass Index to Stratify Obesity-Related Health Risk.Current obesity reports · 2026Review
- Changes in adiposity indices over 10 years and risk of type 2 diabetes: The Whitehall II cohort study.Diabetes, obesity & metabolism · 2025Article
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Abstract
aimsCommon adiposity indices that are used to assess obesity include body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR). We aim to investigate change rates of the three indices in British middle-aged adults and compare effects of different adiposity indices' changes on incident type 2 diabetes. MATERIALS AND
methodsThree repeated measures of BMI, WC and WHtR were collected over a decade (1991-2004) in 5666 participants without diabetes from the Whitehall II cohort study of British civil servants. Linear mixed-effects models were used to estimate standardised individual change rates of the three indices, and participants were then followed up for incident diabetes until 2023. We examined the prospective associations between change rates of the three indices and diabetes by Cox regression analysis.
resultsThe mean change rates for BMI, WC and WHtR were 0.04, 0.06 and 0.07 standard deviation (SD)/year, respectively. There were 633 incident diabetes cases after a median follow-up of 17.6 years. For every 1-SD increase per decade, WC change (HR: 3.01, 95% CI: 2.15-4.22) was associated with a higher diabetes risk than changes in WHtR (HR: 2.67, 95% CI: 2.00-3.55), and BMI (HR: 1.98, 95% CI: 1.53-2.56). No significant interactions were found between the change rates and either sex or age.
conclusionsThe changes in WC and WHtR over a decade were associated with a higher risk of developing diabetes than the change in BMI in this British adult population. Routine monitoring of WC in general practice may provide more benefit than BMI management alone in preventing diabetes.
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