Evidence map›Paper›PMID 40654157›Full record

ReviewCNS neuroscience & therapeutics2025

Roles and Impacts of Integrative Medical Interventions in Central Nervous System Tumor Treatment: Multi-Technology Convergence and the Paradigm Shift Toward Functional Reconstruction.

Junda Lai, Ketao Liu, Yuhua Lin, Zhonglin Chen, Xianglun Ji, Junkai Wen

Abstract readReview
In one paragraph

Review in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junda LaiFujian University of Traditional Chinese Medicine, Fujian, China.
Ketao LiuFujian University of Traditional Chinese Medicine, Fujian, China.
Yuhua LinXiamen TCM Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen, China.
Zhonglin ChenFujian University of Traditional Chinese Medicine, Fujian, China.
Xianglun JiFujian University of Traditional Chinese Medicine, Fujian, China.
Junkai WenShanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID 0000-0003-3763-7673

Funding

Fujian Provincial Health Technology Project 2024QNB021National Natural Science Foundation of China 82405349
6 · The paper itself

Abstract

aimsCentral nervous system (CNS) tumors, particularly glioblastoma, remain a formidable clinical challenge due to their aggressive nature, high heterogeneity, and the restrictive blood-brain barrier. This review aimed to synthesize the roles and impacts of integrative medical interventions in CNS tumor management, highlighting the evolution from traditional monotherapy to multi-technology convergence. It further seeks to address technical barriers and ethical considerations to guide future research and clinical innovation in this field.

methodsThe review discusses a range of integrative medical interventions, including noninvasive neuromodulation, electrotherapy, phototherapy, ultrasound, and magnetotherapy, alongside psychological, nutritional, and herbal medicine approaches. It also evaluates advanced technologies reshaping precision oncology, such as AI-driven diagnostics, 3D organoid models, and multi-omics sequencing, while examining barriers to technical integration and ethical governance issues.

resultsIntegrative medical interventions, combined with multi-technology convergence, play significant roles in CNS tumor management: noninvasive neuromodulation, electrotherapy, phototherapy, ultrasound, and magnetotherapy, together with psychological, nutritional, and herbal approaches, contribute to comprehensive care. Advanced technologies-including AI-driven diagnostics, 3D organoid models, and multi-omics sequencing-enable dynamic disease monitoring, targeted drug delivery, and immune microenvironment remodeling, thereby advancing precision oncology. However, technical integration is hindered by data heterogeneity and translational inefficiency, necessitating standardized frameworks and interdisciplinary collaboration. Additionally, ethical governance is critical for ensuring equitable care.

conclusionThe future landscape of integrative CNS tumor management lies in achieving functional reconstruction through technology-driven innovation, patient-centered care, and global cooperation, with standardized frameworks and interdisciplinary collaboration essential to overcoming existing challenges.

Indexed as

Central Nervous System NeoplasmsIntegrative MedicineAnimalsCombined Modality TherapyHumansPrecision Medicineartificial intelligencecentral nervous system tumorfunctional reconstructionintegrative medicinemulti‐technology convergence

Identifiers

PMID40654157
PMCPMC12256993

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.