Evidence map›Paper›PMID 40654082›Full record

ArticleCirculation research2025

Combinatory Treatment to Alleviate Cellular Stress and Improve Skeletal Muscle Phenotype in Spinal Muscular Atrophy.

Wenshu Zeng, Xiaohui Kong, Arianne Caudal, Shane Rui Zhao, Christina Alamana, Juan Melesio, Lu Ren, Jessica Guzman, Paul D Pang, Kelly Howell and 3 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wenshu Zeng *Stanford Cardiovascular Institute (W.Z., X.K., A.C., S.R.Z., C.A., J.M., L.R., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0003-4029-2397
Xiaohui Kong *Stanford Cardiovascular Institute (W.Z., X.K., A.C., S.R.Z., C.A., J.M., L.R., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0002-8353-3288
Arianne CaudalStanford Cardiovascular Institute (W.Z., X.K., A.C., S.R.Z., C.A., J.M., L.R., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0001-9836-9436
Shane Rui ZhaoStanford Cardiovascular Institute (W.Z., X.K., A.C., S.R.Z., C.A., J.M., L.R., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0002-2137-5536
Christina AlamanaStanford Cardiovascular Institute (W.Z., X.K., A.C., S.R.Z., C.A., J.M., L.R., J.C.W.), Stanford University School of Medicine, CA.
Juan MelesioStanford Cardiovascular Institute (W.Z., X.K., A.C., S.R.Z., C.A., J.M., L.R., J.C.W.), Stanford University School of Medicine, CA.ORCID 0009-0008-1947-1597
Lu RenStanford Cardiovascular Institute (W.Z., X.K., A.C., S.R.Z., C.A., J.M., L.R., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0002-9731-8562
Jessica GuzmanDepartment of Neurology (J.G., J.W.D.), Stanford University School of Medicine, CA.
Paul D PangGreenstone Biosciences, Palo Alto, CA (P.D.P.).
Kelly HowellSpinal Muscular Atrophy Foundation, Jackson, WY (K.H., K.S.C.).
Karen S ChenSpinal Muscular Atrophy Foundation, Jackson, WY (K.H., K.S.C.).
John W DayDepartment of Neurology (J.G., J.W.D.), Stanford University School of Medicine, CA.ORCID 0000-0002-0086-9529
Joseph C WuStanford Cardiovascular Institute (W.Z., X.K., A.C., S.R.Z., C.A., J.M., L.R., J.C.W.), Stanford University School of Medicine, CA.ORCID 0000-0002-6068-8041

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCsR01HL130020 · NHLBI · STANFORD UNIVERSITY · PI Ronglih Liao, MARK MERCOLA · 2016 to 2026
$7.3M
Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated CardiomyopathyR01HL141371 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$6.2M
Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCsR01HL141851 · NHLBI · STANFORD UNIVERSITY · PI WONG, WING H., WU, JOSEPH C. · 2018 to 2025
$5.7M
Unraveling Proteasome Inhibitor-Induced Cardiovascular Toxicity through Integrative MultiomicsR01HL176822 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Joseph C. Wu · 2025 to 2026
$1.4M
Elucidating Drug Interactomes for Cardiac Protection by SGLT2 InhibitorsK99HL179400 · NHLBI · STANFORD UNIVERSITY · PI Arianne Caudal · 2025 to 2026
$262k
Understanding Metabolic Interplay in a Human iPSC Model of Diabetic CardiomyopathyF32HL173968 · NHLBI · STANFORD UNIVERSITY · PI CAUDAL, ARIANNE · 2024 to 2025
$100k
NCI NIH HHS P30 CA124435NHLBI NIH HHS F32 HL173968NHLBI NIH HHS K99 HL179400NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL130020NHLBI NIH HHS R01 HL141371NHLBI NIH HHS R01 HL141851NHLBI NIH HHS R01 HL176822
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

induced pluripotent stem cellsmuscle, skeletalmuscular atrophy, spinalphenotypereactive oxygen species

Identifiers

PMID40654082
PMCPMC12295002

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.