Evidence map›Paper›PMID 40654044›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2025

What Is the Safest Population-Level Caesarean Delivery Rate? A National Cohort Study Using Natural Variation.

Dag Moster, Allen J Wilcox, Rolv Terje Lie

Abstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Dag MosterDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Allen J WilcoxEpidemiology Branch (Emeritus Investigator), National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.
Rolv Terje LieDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.ORCID https://orcid.org/0000-0001-6287-4051

Funding

Epidemiology Of Reproductive Outcomes /Environ ExposuresZ01ES044003 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WILCOX, ALLEN J · 1985 to 2008
$786k
Intramural NIH HHS Z01 ES044003NIEHS NIH HHSTrond Mohn Research Foundation TMS2023TMT08Western Norway Regional Health Authority
6 · The paper itself

Abstract

objectiveTen to fifteen per cent has been proposed for many decades as the optimal level of caesarean section, with little supporting data. Norway provides a natural experiment in which local variations in the use of caesarean section can be related to health outcomes in the context of free access to high-quality medical services.

designProspective national cohort.

settingNorway. POPULATION: Norwegian deliveries 1995-2014.

methodsWe calculated annual rates of caesarean delivery and health outcomes for 435 municipalities. To avoid hospital referral bias, the mother's municipality of residence was the unit of analysis. Caesarean-delivery rates in each year were based on the 2 years before and after, avoiding indication bias. Analyses were adjusted for year, with additional adjustments in sensitivity analyses.

main outcome measuresMaternal mortality, severe maternal haemorrhage and perineal tears; stillbirth and neonatal death, neonatal encephalopathy and cerebral palsy.

resultsThere were 1 172 546 deliveries across 8647 municipality-year combinations over a 20-year period. Caesarean rates across municipalities ranged from about 10% to 20%, with quartile values of 13%, 16% (median) and 18%. Most adverse outcomes were least frequent in municipalities with caesarean rates above 15%. Lower rates of caesarean delivery were associated with more frequent occurrence of perineal tears (OR 1.41, 95% confidence interval 1.36-1.46), neonatal encephalopathy (OR 1.91, 1.71-2.13), cerebral palsy (1.48, 1.24-1.77) and stillbirths (OR 1.07, 0.99-1.17), but also with less frequent maternal haemorrhage (OR 0.81, 0.77-0.85). Further adjustments had minimal effect on estimates.

conclusionIn Norway, a country with free access to high-quality medical care, a local caesarean-delivery rate of 10% was associated with nearly a two-fold risk of neonatal encephalopathy and a 50% higher occurrence of cerebral palsy compared with areas with a caesarean-delivery rate of 20%.

Indexed as

Cesarean SectionAdultCerebral PalsyFemaleHumansInfant, NewbornMaternal MortalityNorwayPerineumPregnancyProspective StudiesStillbirthcaesarean deliverycerebral palsymaternal healthneonatal encephalopathyperinatal health

Identifiers

PMID40654044
PMCPMC12358162

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