ArticleInternational wound journal2025
The Association of Systemic Inflammation, Wound Bioburden and Total Bacterial Counts With Healing Outcomes in Older Adults With Chronic Venous Leg Ulcers.
Article in International wound journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.Bioactive materials · 2027Review
- Predictors of Short-Term Outcome in Venous Leg Ulcers: The Dominant Role of Wound Infection and Multiple Ulcers.Journal of clinical medicine · 2026Article
- The Wound-Heart Axis: Can Chronic Wounds Contribute to Cardiac Dysfunction?International journal of molecular sciences · 2026Review
- Cold Atmospheric Plasma Disrupts Microbial Wound Bioburden: In Vitro, Porcine MRSA Biofilm, and Clinical Fluorescence Evidence from Bench to Bedside.Biomedicines · 2026Article
- The Vicious Cycle of Biofilm, Host Inflammation and Microvascular Insufficiency in Venous Leg Ulcers.Medical sciences (Basel, Switzerland) · 2026Review
- The Association of Systemic Inflammation, Wound Bioburden and Total Bacterial Counts With Healing Outcomes in Older Adults With Chronic Venous Leg Ulcers.International wound journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
This substudy utilised data from a prospective, longitudinal study aimed to investigate associations between systemic inflammation, wound bioburden, total bacterial counts and wound healing outcomes over 8 weeks in older adults with chronic venous leg ulcers (CVLUs). Participants were receiving standardised weekly wound debridement. Blood and wound tissue samples were collected at baseline and Weeks 2, 4, 6 and 8, or until the wound was healed. Wound healing status was categorised by two parameters: healed versus nonhealed and healing versus nonhealing. A linear mixed model assessed associations among clinical and laboratory variables with wound healing status over time. Of the 117 participants, 47 (40%) had wounds that healed within the 8-week period. In nonhealed wounds, C-reactive protein (CRP) was positively associated with total bacterial counts (p < 0.001), wound bioburden (p = 0.01) and wound diameter (p = 0.004) over time. Total bacterial counts were positively associated with CRP (p = 0.023), interleukin-6 (IL-6) (p = 0.034) and tumour necrosis factor-alpha (TNF-α) (p < 0.001) in nonhealing wounds. The results suggest that CRP, IL-6 and TNF-α may be useful markers in predicting wound healing trajectories. Ongoing monitoring of inflammatory markers and bacterial counts could aid in assessing wound healing progress in older adults with CVLUs.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.