ArticleThe European journal of neuroscience2025
Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus.
Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Subcellular Localization of Dopamine D1 and D2 Receptors in the Mouse Hippocampus.The Journal of comparative neurology · 2026Article
- Cannabidiol dampens propagation of hippocampal hyperactivity and differentially modulates feedforward and feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
- Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus.The European journal of neuroscience · 2025Article
- Mouse spinal cord cellular mapping of dopamine D2 receptors-containing cells.Frontiers in neuroanatomy · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Spatiomolecular mapping of hippocampal dopamine D2 receptor neurons revealed that in addition to hilar mossy cells, hippocampal somatostatin interneurons and, to a lesser extent, parvalbumin interneurons expressed dopamine D2 receptor. However, the consequence of dopamine D2 receptor activation on hippocampal somatostatin interneurons and parvalbumin interneurons is unknown. By combining pharmacological approaches and patch-clamp recordings in organotypic hippocampal slices from control mice or mice lacking Drd2 selectively in somatostatin or parvalbumin interneurons, we found that dopamine D2 receptor activation increases excitability in somatostatin interneurons while it decreases it in parvalbumin interneurons in the CA1 area. These changes depend on voltage-gated K channels and rely on distinct intracellular pathways, involving the non-canonical β-arrestin-dependent pathway in somatostatin interneurons and the G protein-dependent pathway in parvalbumin interneurons. Finally, our study unveils that activation of dopamine D2 receptor in somatostatin interneurons modulates methacholine-induced rhythmic synaptic activity at 4-15 Hz.
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