Evidence map›Paper›PMID 40653782›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings.

Yichao Wang, Yi Wang, Fengling Yang, Jingbo Chen, Xiaoyu Geng, Qing Sun, Jinyu Zhang, Chang Liu, Jie Lv, Xiaochuan Hou and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yichao WangFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Yi WangFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Fengling YangFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Jingbo ChenFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Xiaoyu GengFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Qing SunDepartment of Military and Special Medicine, No.971 Hospital of the PLA Navy, Qingdao, Shandong, 266071, China.
Jinyu ZhangFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Chang LiuFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Jie LvFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Xiaochuan HouFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Yongfang WangFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Huiyan LinDepartment of Intensive Care Medicine, No.971 Hospital of the PLA Navy, Qingdao, Shandong, 266071, China.
Jing ZhangCollege of Traditional Chinese Medicine, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Lingxin ChenCAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Research Center for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, 264003, China.
Bing YanInstitute of Environmental Research at the Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, Guangdong, 510006, China.
Liang XiaoFaculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.ORCID https://orcid.org/0009-0005-0532-8616

Funding

Shanghai Municipal Health Commission Research Project Fund 202240144Shanghai's Science and Technology Innovation Action Plan International Science and Technology Cooperation Project 24410710100
6 · The paper itself

Abstract

Fatal jellyfish stings often cause multi-organ failure. Until now, these fatal outcomes are attributed to the direct toxic effects of the venom. Here, a mouse model of delayed jellyfish envenomation syndrome (DJES) is established and showed that venom from Nemopilema nomurai jellyfish can trigger a deadly cytokine storm - a severe inflammatory reaction. Mice injected with the venom displayed acute multi-organ failure and significant upregulation of over 20 pro-inflammatory cytokines (including IL-6, TNF-α, CXCL2, and CCL4) in the heart, liver, and kidneys. Transcriptomic analyses identified NF-κB p65 subunit activation as central to the cytokine storm induction. Knockdown of p65 in macrophages reduced cytokine production and improved cell viability. Treatment with dexamethasone, an NF-κB inhibitor, effectively suppressed the cytokine storm, mitigated organ damage, and increased survival rates in mice. The findings present new insights to treat fatal jellyfish stings.

Indexed as

Bites and StingsCnidarian VenomsCytokine Release SyndromeCytokinesMultiple Organ FailureScyphozoaAnimalsDisease Models, AnimalMiceCnidarian VenomsCytokinescytokine stormenvenomationinflammationjellyfishNF‐κB p65

Identifiers

PMID40653782
PMCPMC12499386

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.