ArticleVirulence2025
Outbreak and epidemic of Getah virus infection in swine by virulence-enhanced GIII variant in Henan, central China in 2024.
Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of Getah Virus in Mammals in East and Southeast Asia: A Systematic Review and Meta-Analysis.Transboundary and emerging diseases · 2026Pooled it
- The 3'Untranslated region is a critical determinant of Getah virus replication, pathogenesis, and vector competence.Virulence · 2026Article
- N-linked glycosylation of GETV envelope proteins affect viral infection and pathogenicity.Virulence · 2026Article
- A conserved E1 stem motif functions as a virulence switch in the emerging Getah virus.Virulence · 2026Article
- Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay.Journal of virology · 2026Review
- Development and validation of an E2 based indirect ELISA for serological detection of porcine Getah virus.Veterinary research communications · 2026Article
- Isolation and Molecular Characterization of Emerging Getah Virus Genotype III Variant Strains from Swine in Southeastern China (2024-2025).International journal of molecular sciences · 2026Article
- Establishment and Application of an Indirect ELISA for Detecting Getah Virus IgG Antibodies in Swine Based on the E2EP3 Peptide.Veterinary sciences · 2026Article
- Re-Emergence and Characterization of a Highly Pathogenic Getah Virus on a Pig Farm in Guangdong Province, China.Microorganisms · 2026Article
- Mosquito-borne viral infections: veterinary diagnostic approach with a One Health perspective.Journal of clinical microbiology · 2026Review
- Reservoirs of Getah virus: an update review.Frontiers in veterinary science · 2026Review
- Highly Virulent Getah Virus Subgroup GIII-c Emerging in Pigs in China.Transboundary and emerging diseases · 2026Article
- Getah Virus in Review: An Emerging Zoonotic Arbovirus.Transboundary and emerging diseases · 2026Review
- Article
- Establishment of reverse transcription recombinase-aided amplification with lateral flow dipstick for the rapid visual detection of Getah virus.Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Getah virus (GETV), an emerging mosquito-borne virus, poses a threat to many animal species and probably even humans. Between late July and mid-September, concentrated outbreaks of GETV on pig farms have occurred in multiple regions across Henan, and showed epidemic characteristics. To investigate the genetic characteristics and virulence changes of GETV strains responsible for the GETV epidemic in Henan, a total of 27 GETV strains were isolated from 31 commercial pig farms located in 21 counties. Phylogenetic and sequence alignment analysis results showed that 22 of the isolates formed a distinct cluster within the phylogenetic tree, and the strains in this cluster exhibited 3 amino acid mutations in the non-structural protein nsP3 along with an amino acid mutation in the structural protein E2. Piglet pathogenicity experiments demonstrated that the isolate could induce the characteristic clinical signs of GETV infection in piglets, resulting in 100% mortality. Comparative analysis of pathogenicity in mice showed that the pathogenicity of the GETV GIII variant was significantly enhanced compared with the early isolate. This study is the first to investigate in detail the large-scale, concentrated outbreak and epidemic of GETV infection in pig farms in Henan and confirms that there is a trend of increasing virulence of the GIII variant responsible for this outbreak. The data in this study will contribute to the understanding of the molecular epidemiological characteristics and pathogenicity dynamics of GETV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.