ArticleEquine veterinary journal2026
Pregabalin contributes to increased recovery time from isoflurane anaesthesia for magnetic resonance imaging in horses.
Article in Equine veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregabalin reduces excitatory neurotransmitter release and is used for anxiolysis in humans, cats, and horses. The effects of pregabalin on equine recovery following isoflurane anaesthesia are unknown.
objectivesTo determine if pre-anaesthetic oral pregabalin influences recovery time and/or quality from isoflurane anaesthesia in horses undergoing elective magnetic resonance imaging (MRI) of the appendicular skeleton. STUDY
designRetrospective cohort study.
methodsAnaesthetic and recovery data from 52 healthy horses in which pregabalin (PG) was administered and 76 control horses (CG) undergoing elective MRI from July 2023 to August 2024 were reviewed. Recordings of the recovery period were blindly scored by three reviewers. Multivariable linear regression analysis was used to identify factors that impact recovery times.
resultsPG received (median [range]) 3 (1-5) doses of 3.94 (3.56-4.28) mg/kg pregabalin. More CG required butorphanol (23/76 versus PG 4/52 p = 0.008) to achieve appropriate sedation for induction and ketamine boluses during the procedure (25/76 versus 8/52, p = 0.03). PG had longer times to stand (60 [48-71] min versus CG 53 [45-64], p = 0.02). There were no significant differences in recovery quality scores between groups. Age, pregabalin, acepromazine, xylazine, time to first movement and time to extubation were significantly associated with an increased time to stand (R MAIN LIMITATIONS: The retrospective nature, limited number of cases, and overall excellent quality of recoveries may have limited detection of differences between groups. Administration of butorphanol, xylazine, and acepromazine at the discretion of an unblinded anaesthetist may have influenced the time to stand.
conclusionsPregabalin contributed to increased recovery times when administered to a group of healthy horses. Recovery quality scores were excellent overall, and there was no difference between groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.