Evidence map›Paper›PMID 40653703›Full record

ArticleACS infectious diseases2025

Extracellular vesicles from Distinct

Taiane N Souza, Alessandro F Valdez, Ana Claudia G Zimbres, Bianca A G Sena, Flavia C G Reis, Marcio L Rodrigues, Daniel Zamith-Miranda, Allan J Guimarães, Alessandra A Filardy, Joshua D Nosanchuk and 1 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Extracellular Vesicles fromJournal of fungi (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Taiane N SouzaInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0002-5500-7758
Alessandro F ValdezInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Ana Claudia G ZimbresInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Bianca A G SenaInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Flavia C G ReisInstituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba 81310-020, Brazil.
Marcio L RodriguesInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0002-6081-3439
Daniel Zamith-MirandaDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, New York 10461, United States.
Allan J GuimarãesDepartamento de Microbiologia e Parasitologia─MIP, Instituto Biomédico, Universidade Federal Fluminense, Rio de Janeiro 24210-130, Brazil.
Alessandra A FilardyInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Joshua D NosanchukDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, New York 10461, United States.
Leonardo NimrichterInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.ORCID 0000-0001-9281-6856

Funding

The biology of Cryptococcus neoformans melanizationR01AI171093 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall, JOSHUA D NOSANCHUK · 2023 to 2026
$3.2M
Candida auris extracellular vesicles subvert host immune responsesR21AI156104 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI NOSANCHUK, JOSHUA D · 2021 to 2022
$462k
An extracellular vesicle component as a candidate to control cryptococcosis.R01AI183314 · NIAID · FUNDACAO OSWALDO CRUZ · PI JOSHUA D NOSANCHUK, Marcio Lourenco Rodrigues · 2024 to 2026
$380k
NIAID NIH HHS R01 AI171093NIAID NIH HHS R01 AI183314NIAID NIH HHS R21 AI156104
6 · The paper itself

Abstract

Fungal extracellular vesicles (EVs) are lipid-bilayer compartments that transport a wide range of molecules, including proteins, polysaccharides, pigments, small metabolites, lipids, and RNA. In fungal pathogens, EVs harbor virulence factors as well as antigenic determinants that modulate the host immune response. In this work, we investigated the modulatory effects of EVs released by two phenotypically and genotypically distinct strains of

Indexed as

Extracellular VesiclesHistoplasmaHistoplasmosisMacrophagesPhagocytesAnimalsDendritic CellsHost-Pathogen InteractionsInterleukin-10Interleukin-6MiceMice, Inbred C57BLPhagocytosisInterleukin-10Interleukin-6extracellular vesiclesHistoplasma capsulatuminnate immunityvirulence

Identifiers

PMID40653703
PMCPMC12340971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.