Evidence map›Paper›PMID 40653657›Full record

ArticleJournal of hepato-biliary-pancreatic sciences2025

Patients With Pancreatic Cancer With Synchronous Liver Oligometastasis Show a Significant Long-Term Survival Benefit From Resection Under Specific Conditions: A Multicenter National Cohort Study.

Kohei Nakata, Yoshihiro Miyasaka, Takeaki Ishizawa, Masayuki Ohtsuka, Masamichi Mizuma, Sohei Satoi, Masaaki Hidaka, Shuji Suzuki, Hiroshi Kurahara, Chie Kitami and 29 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hepato-biliary-pancreatic sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Kohei NakataDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoshihiro MiyasakaDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takeaki IshizawaDepartment of Hepatobiliary-Pancreatic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Masayuki OhtsukaDepartment of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Masamichi MizumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Sohei SatoiDepartment of Pancreatobiliary Surgery, Kansai Medical University, Osaka, Japan.ORCID https://orcid.org/0000-0001-6527-5409
Masaaki HidakaDepartment of Digestive and General Surgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.ORCID https://orcid.org/0000-0001-8191-6405
Shuji SuzukiDepartment of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-3201-9908
Hiroshi KuraharaDepartment of Digestive Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Chie KitamiDepartment of Surgery, Nagaoka Chuo General Hospital, Nagaoka, Japan.
Satoshi HiranoDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo, Hokkaido, Japan.
Dongha LeeDepartment of Surgery, Kindai University Faculty of Medicine, Osakasayama, Japan.ORCID https://orcid.org/0000-0001-6796-1891
Saiho KoDepartment of Surgery, Nara Prefecture General Medical Center, Nara, Japan.
Munenori TaharaDepartment of Surgery, Sapporo-Kosei General Hospital, Sapporo, Japan.
Isaku YoshiokaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Kenjiro DateDepartment of Surgery, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
Kazuyuki NagaiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Goro HondaDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Shugo MizunoDepartment of Hepatobiliary Pancreatic & Transplant Surgery, Mie University, Tsu, Mie, Japan.
Kenichi HakamadaDepartment of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Yasuro FutagawaDepartment of Surgery, Jikei University Daisan Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1994-6309
Shigeru MarubashiDepartment of Hepato-Biliary-Pancreatic and Transplant Surgery, Fukushima Medical University, Fukushima, Japan.
Hiroshi YoshidaDepartment of Surgery, Iwaki City Medical Center, Iwaki, Japan.
Akihiko HoriguchiDepartment of Gastroenterological Surgery, Fujita Health University Bantane Hospital, Nagoya, Japan.
Yasuo HosouchiDepartment of Surgery, Gunma Prefecture Saiseikai Maebashi Hospital, Maebashi, Japan.
Masafumi ImamuraDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
Naoto GotohdaDepartment of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.ORCID https://orcid.org/0000-0002-4468-5844
Hiroaki NaganoDepartment of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
Masaji TaniDepartment of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
Takeshi SudoDepartment of Surgery, NHO Kure Medical Center Chugoku Cancer Center, Hiroshima, Japan.
Teijiro HirashitaDepartment of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Oita, Japan.
Junichi AritaDepartment of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita, Japan.ORCID https://orcid.org/0000-0003-1929-8479
Katsutoshi MuraseDepartment of Gastroenterological Surgery, Graduate School of Medicine, Gifu University, Gifu, Japan.
Ken FukumitsuDepartment of Surgery, Kyoto Katsura Hospital, Kyoto, Japan.ORCID https://orcid.org/0000-0002-7629-1356
Toshiki RikiyamaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Teruyuki UsubaDepartment of Surgery, Katsushika Medical Center, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Toshiya AbeDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masafumi NakamuraDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Itaru EndoJapan Society of Hepato-Biliary-Pancreatic Surgery, Osaka, Japan.ORCID https://orcid.org/0000-0001-5520-8114

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we investigated the criteria that predict the long-term survival benefits after surgical resection in patients with pancreatic cancer accompanied by liver oligometastasis.

methodsIn total, 60 patients from 34 high-volume Japanese centers who underwent surgical resection for liver oligometastasis between 2005 and 2020 were included. Univariate and multivariate methods of survival analyses were performed. All patients were followed up for at least 36 months.

resultsOverall survival (OS) was significantly longer in the preoperative chemotherapy group than in the up-front surgery group (37.4 vs. 20.4 months, p = 0.001). In the operation with preoperative chemotherapy group, a complete response was observed in eight patients (28.6%). The 1-, 3-, and 5-year OS rates were 92.9%, 50.0%, and 35.7%, respectively. The multivariate analysis showed that low CA19-9 (< 100 U/mL; HR: 0.25; 95% CI: 0.06-0.96; p = 0.043), low CEA (< 5 U/mL; HR: 0.14; 95% CI: 0.04-0.48; p = 0.002), and resectable (R) or borderline resectable pancreatic cancer invading the portal vein (BR-PV) status (HR: 0.19; 95% CI: 0.07-0.51; p < 0.001) were positive prognostic factors. The median OS of the patients who met all three criteria was 106.6 months.

conclusionPreoperative chemotherapy is essential for the treatment of liver oligometastases. Despite the high recurrence rates, patients who met the specific criteria have a favorable prognosis with liver resection.

Indexed as

HepatectomyLiver NeoplasmsPancreatic NeoplasmsAgedCohort StudiesFemaleHumansJapanMaleMiddle AgedPancreatectomyPrognosisRetrospective StudiesSurvival Rateoligometastasispancreatic cancerpreoperative chemotherapy

Identifiers

PMID40653657
PMCPMC12380032

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.