ArticlePediatric transplantation2025
Low Absolute Lymphocyte Count Associated With Anti-Thymocyte Globulin Induction May Be a Predictor of Early Cytomegalovirus Infection in Pediatric Heart Transplantation.
Article in Pediatric transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCytomegalovirus (CMV) can cause serious morbidity in transplant patients. Lymphocyte depletion by anti-thymocyte globulin (ATG) may persist for 6 months post-induction, and lower absolute lymphocyte counts (ALC) may increase the risk for CMV. We sought to find the relationship between ALC at induction and CMV viremia in the first 6 months post-transplant.
methodsAn analysis of transplant recipients within a set period of time with uniformed induction therapy and CMV prophylaxis. ATG was a primary component of induction and ganciclovir or valganciclovir as prevention of CMV infection. The cohort was dichotomized into low ALC (≤ 0.3 × 10
resultsA total of 44 patients were included in this study. CMV viremia occurred in 18% (n = 8). Patients were more likely to develop CMV if post-induction ALC was ≤ 0.3 × 10
conclusionIn pediatric heart transplant recipients, there is a higher incidence of CMV if ALC ≤ 0.3 × 10
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