SynthesisObesity (Silver Spring, Md.)2025
Adiposity associations with risk of colorectal cancer: a systematic review.
Synthesis in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Glucagon-like peptide 1 receptor agonists and cancer risk: the good, the bad and the unknown.Nature reviews. Clinical oncology · 2026Review
- Somatostatin in Aging: Correlations with Selected Central Nervous System and Gastrointestinal Tract Diseases.International journal of molecular sciences · 2026Review
- Dual-energy X-ray Absorptiometry-Derived Adiposity and Colorectal Cancer Incidence and Mortality in Postmenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveThis systematic review evaluates the relationship between adiposity and incident colorectal cancer (CRC) risk.
methodsMEDLINE, Scopus, Embase, CINAHL, and CENTRAL were searched for articles that met the following criteria: 1) assessed adiposity measures; 2) included incident data for any diagnosed malignant stage of CRC, colon cancer, or rectal cancer; and 3) studied adults aged older than 18 years. Articles were assessed for bias using the National Institutes of Health study quality assessment tools.
resultsFifteen articles across ten studies met the inclusion criteria. Three significant associations were positive, one was negative, and eleven were nonsignificant and positive. Measures varied based on the tool, and these four tools were used to gather body composition measures: bioelectrical impedance, computerized tomography, dual-energy x-ray absorptiometry, and ultrasound. The most used were total body fat mass and percent fat, along with abdominal visceral and subcutaneous adipose tissues. Overall, higher levels of adipose were positively associated with an increased risk of CRC. The strength of associations and significance varied by body composition variable, measurement technique, tumor location, and sex.
conclusionsStandardization is needed to better elucidate the relation between CRC and adiposity to allow for comparisons across papers. Additionally, a balance among precision, accessibility, and cost of measurements must be struck.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.