Trial reportScientific reports2025
Flupentixol/melitracen for epigastric pain syndrome in female patients with abnormal urinalysis and therapeutic insights into the brain-bladder axis.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of abnormal urinalysis in female epigastric pain syndrome (EPS) is unclear. This study aimed to observe the effect of flupentixol/melitracen (FM) acting in central nervous system on urinalysis in female EPS. It is confirmed that abnormal urinalysis indicators may be related to somatization caused by abnormal brain-bladder axis. A total of 125 female patients with EPS were randomly assigned to the test and control groups. Patients in the control group (n = 62) received omeprazole for 4 weeks. On this basis, cases in the test group (n = 63) received FM. The changes of dyspepsia symptoms, somatization symptoms and urinalysis were observed at 0 and 4 weeks. In this clinical trial, the score of DSS, somatization symptoms and urinary inflammatory indicators could improve after received FM in female EPS patients with abnormal urinalysis indicators. These results suggest that the brain-bladder axis might contribute to the pathogenesis of EPS, combined with effective anti-somatization or anti-depression treatment is necessary in some female EPS patients with abnormal urinalysis. Further studies are needed to confirm about brain-gut-bladder axis in EPS pathogenesis. Clinical Trials.gov (number: ChiCTR2400079677).
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