Evidence map›Paper›PMID 40653502›Full record

ArticleNPJ vaccines2025

Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines.

Guy de Bruyn, Haritha Adhikarla, Caroline K Brackett, Yichen Jia, Premkumar Lakshmanane, Sarah V Mudrak, Sheetal Sawant, Donghui Zhang, Roman M Chicz, Saranya Sridhar and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guy de BruynSanofi Vaccines Research & Development, Swiftwater, PA, USA. guy.debruyn@sanofi.com.ORCID http://orcid.org/0000-0002-8028-4474
Haritha AdhikarlaSanofi Vaccines Research & Development, Swiftwater, PA, USA.
Caroline K BrackettDepartment of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA.
Yichen JiaSanofi Vaccines Research & Development, Swiftwater, PA, USA.
Premkumar LakshmananeDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.
Sarah V MudrakDepartment of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA.
Sheetal SawantDepartment of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA.
Donghui ZhangSanofi Vaccines R&D, Orlando, FL, USA.
Roman M ChiczSanofi Vaccines R&D, Waltham, MA, USA.
Saranya SridharSanofi Vaccines R&D, Reading, UK.ORCID http://orcid.org/0000-0002-4267-3102
Georgia D Tomaras *Department of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8076-1931
Kelly E Seaton *Department of Surgery and Integrative Immunobiology, Center for Human Systems Immunology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-2009-3270

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
NIAID NIH HHS UM1 AI068619U.S. Department of Health & Human Services | Biomedical Advanced Research and Development Authority (BARDA) HHSO100201600005I
6 · The paper itself

Abstract

We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.

Identifiers

PMID40653502
PMCPMC12256584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.