ReviewTrends in biochemical sciences2025
Proteasome-derived peptides: separating the trash from the recycling.
Review in Trends in biochemical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Stimulating proteasomal degradation in human proteinopathies.The FEBS journal · 2026Review
- Review
- Sex-specific remodeling of proteasome complexes in lymph nodes of aged BTBR mice.Frontiers in aging · 2026Article
- Cleaving Expectations: A Review of Proteasome Functional and Catalytic Diversity.Biomolecules · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The proteasome is an essential protein complex in all cells. Proteasomes have two main functions: protein degradation and peptide generation. While proteasome-dependent protein degradation removes proteins and is critical for cellular function, the newly generated proteasome-derived peptides, which range in size and sequence, are emerging as essential cellular effector molecules: they are expressed on MHC-I in the immune system, function as novel modulators of neuronal signaling, are involved in innate immunity and intracellular signaling, and can be metabolized further for important cellular processes. Here, we take a comprehensive look at the mechanics behind proteasome-mediated peptide generation; the function of proteasome-derived peptides in signaling and metabolism relevant to cellular biology, health, and disease; and the techniques enabling these studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.