Social Isolation, Loneliness, and Cognitive Health.

Mfon E Umoh

Abstract readReview

In one paragraph

Review in Clinics in geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Nuclear accumulation of PANK4 in hippocampal astrocytes aggravates cuproptosis in association with mild cognitive impairment in aged mice.Frontiers in aging neuroscience · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Mfon E UmohDivision of Geriatric Medicine and Gerontology, Department of Medicine, The Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Center Tower 205 Mason Lord Building, Baltimore, MD 21224, USA. Electronic address: mumoh3@jhmi.edu.

Funding

Health Services and Outcomes Research for Aging PopulationsT32AG066576 · NIA · JOHNS HOPKINS UNIVERSITY · PI CYNTHIA Melinda BOYD, Jennifer L. Wolff · 2020 to 2026

$3.8M

NIA NIH HHS L30 AG089733NIA NIH HHS T32 AG066576

6 · The paper itself

Abstract

Social connectedness is important for maintaining cognitive function and cognitive health in older age. In particular, social isolation (the objective lack of relationships) and loneliness (the subjective perception of lacking social connection) among older adults are important public health challenges that have been linked to increased cognitive decline and dementia risk in many studies. In this review, the authors examine studies of the relationship between these social risk factors and cognitive decline, examine the cognitive impact of interventions targeted toward social disconnection, explore the mechanisms underlying these relationships, and provide clinical recommendations for identifying and targeting social disconnection.

Indexed as

AgingCognitionCognitive DysfunctionDementiaLonelinessSocial IsolationAgedHumansRisk FactorsCognitive declineDementiaLonelinessSocial connectionSocial disconnectionSocial isolation

Identifiers

PMID40653340

DOI10.1016/j.cger.2025.04.007

PMCPMC12570207

What OpenQuestion holds

Textmetadata

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.