ArticleJournal of molecular and cellular cardiology2025
Psychosocial stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse heart.
Abstract read
In one paragraph
Article in Journal of molecular and cellular cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Daphne DilorettoDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA.
Gaurav SarodeDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA.
Phung N ThaiDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA.
Jeong Han LeeDepartment of Translational Neuroscience, University of Arizona, Phoenix, AZ, USA.
Evelyn NavarDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA.
Jeong Eun ParkDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA.
Chaitali KhadilkarDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA.
Ning ZongDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA.
Yu Jia DongDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA.
Avni DudaDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA.
Erick RomeroAHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA.
Pablo E AcevedoDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA.
Xiao-Dong ZhangDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA.
David A LiemDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA.
Imo EbongDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA.
Javier E LopezDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA.
Heejung BangAHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA; Department of Public Health Sciences, Division of Biostatistics, University of California, Davis, CA, USA.
Chao-Yin ChenAHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; Department of Pharmacology, University of California, Davis, CA, USA.
Leighton IzuAHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA; Department of Pharmacology, University of California, Davis, CA, USA.
Martin CadeirasDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA.
Ebenezer N YamoahAHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; Department of Translational Neuroscience, University of Arizona, Phoenix, AZ, USA.
Nipavan ChiamvimonvatDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA; Department of Basic Medical Sciences, University of Arizona, Phoenix, AZ, USA.
Padmini SirishDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, CA, USA; AHA Strategically Focused Research Network to study Chronic Psychosocial Stressors, Sacramento, CA, USA; University of California, Davis HeartShare Clinical Center: Next Generation Phenomics to Define HFpEF, Sacramento, CA, USA. Electronic address: psirish@ucdavis.edu.
Funding
Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3MStructural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI PERKINS, GUY A · 2016 to 2025
$15.5MFunctional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3MTranslational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7MInner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7MThe Functional Connectome of the Mechanically Loaded CardiomyocyteR01HL149431 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE, IZU, LEIGHTON T. · 2020 to 2023
$2.7MMechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5MA prospective multiethnic HFpEF cohort from Californias Central ValleyU01HL160274 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, Nipavan Chiamvimonvat · 2021 to 2026
$2.3MDecoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2MCalcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1MRegulation of hair cell functionsR01DC015252 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2017 to 2021
$2.1MMolecular Mechanisms of Atrial Fibrillation: A Multimodal AnalysisR01HL170520 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nipavan Chiamvimonvat, Vladimir Filkov · 2024 to 2026
$1.8MBLRD VA I01 BX000576CSRD VA I01 CX001490NCRR NIH HHS S10 RR022498NHLBI NIH HHS F31 HL168956NHLBI NIH HHS F31 HL170698NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL137228NHLBI NIH HHS R01 HL149431NHLBI NIH HHS R01 HL158961NHLBI NIH HHS R01 HL170520NHLBI NIH HHS R56 HL138392NHLBI NIH HHS R56 HL167932NHLBI NIH HHS U01 HL160274NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC015252NIDCD NIH HHS R01 DC016099NIGMS NIH HHS P20 GM130459
Abstract
Psychosocial stress (PSS) affects all humans with different intensities and is known to significantly increase inflammation and cardiovascular disease [1,2]. An amplifier of inflammation is an intracellular multiprotein complex, the inflammasome, activation of which leads to pro-inflammatory cytokines production. However, the mechanisms leading to the inflammasome activation in the heart by PSS are not well understood. Here, we identify critical upstream mechanisms leading to NLRP3 inflammasome activation via endoplasmic reticulum (ER) stress and JAK/STAT pathway. These findings reveal important mechanistic insights into possible upstream targets in controlling excessive inflammation due to PSS.
Indexed as
Endoplasmic Reticulum StressInflammasomesInflammationMyocardiumNLR Family, Pyrin Domain-Containing 3 ProteinStress, PsychologicalAnimalsCytokinesHumansJanus KinasesMiceMice, Inbred C57BLSignal TransductionSTAT Transcription FactorsCytokinesInflammasomesJanus KinasesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSTAT Transcription FactorsER stressInflammasomeInflammationOxylipins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.