Evidence map›Paper›PMID 40653253›Full record

ArticleClinical immunology (Orlando, Fla.)2025

Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium.

Fatima Zaman, Xianming Zhu, Joanne H Hunt, Gracie Rozek, Yolanda Eby, Sarah Hussain, Niraj M Desai, Sander Florman, Meenakshi M Rana, Rachel Friedman-Moraco and 21 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Fatima ZamanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Xianming ZhuDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Joanne H HuntLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Gracie RozekDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yolanda EbyDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sarah HussainDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Niraj M DesaiDepartment of Surgery, Northwell Transplant Institute, Manhasset, NY, USA.
Sander FlormanRecanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Meenakshi M RanaDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rachel Friedman-MoracoDepartment of Medicine, Emory University, Atlanta, GA, USA.
Marcus R PereiraDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Shikha MehtaDepartment of Medicine, University of Alabama Heersink School of Medicine, Birmingham, AL, USA.
Peter StockDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Alexander GilbertMedstar Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA.
Jonathan HandOchsner Health, New Orleans, LA, USA.
Michele I MorrisDepartment of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA.
Valentina StosorDepartments of Medicine and Surgery, Divisions of Infectious Diseases and Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Sapna A MehtaNYU Langone Transplant Institute, New York, NY, USA.
Catherine B SmallDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.
Joanna SchaenmanUniversity of California Los Angeles, Los Angeles, CA, USA.
Carlos A Q SantosDivision of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA.
Saima AslamDepartment of Medicine, University of California, San Diego, San Diego, CA, USA.
David WojciechowskiDepartment of Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Maricar MalinisDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Ghady HaidarDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jonah OdimDivision of Extramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Megan MorsheimerDivision of Extramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Dorry L SegevNYU Langone Transplant Institute, New York, NY, USA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Andrew D ReddLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Christine M DurandDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Aaron A R TobianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
HOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5M
Kidney Transplantation from Donors with HIV: Impact on Rejection and Long-term OutcomesU01AI177211 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2023 to 2026
$6.9M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
T-cell depletion and maintenance of the HIV-1 latent reservoir in distinct tissue compartmentsR01DK131926 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Melissa Laird Smith, AARON A TOBIAN · 2022 to 2026
$3.6M
Function of Stem Cell-Derived Neurons in the Aging BrainR01AG020938 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GAGE, FRED H · 2002 to 2006
$2.1M
NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI120938NIAID NIH HHS U01 AI138897NIAID NIH HHS U01 AI177211NIA NIH HHS R01 AG020938NIDDK NIH HHS R01 DK131926
6 · The paper itself

Abstract

Kidney transplantation from donors with HIV has recently become standard clinical practice, but the plasma inflammatory profile is not well characterized. Thirty-two cytokines and chemokines were evaluated among donors with HIV (n = 63) and without HIV (n = 41). Wilcoxon rank sum test was used to compare cytokines between groups. Donors with and without HIV were generally similar in terms of characteristics, except those with HIV had a non-significantly lower kidney donor profile index, reflecting better graft survival, creatinine, and body mass index. Most cytokine and chemokine levels were similar between groups. However, median IL-8 levels were higher (p < 0.0015) in donors without HIV (32.6 pg/mL, IQR = 13.8-394.9) compared to donors with HIV (15.1 pg/mL, IQR = 8.4-35.5). There were no significant correlations between cytokine and chemokine concentrations and CD4 counts or HIV viral load. In summary, inflammatory profiles were similar or lower among donors with HIV compared to donors without HIV supporting the safety of this emerging kidney transplantation practice.

Indexed as

HIV InfectionsInflammationKidney TransplantationTissue DonorsAdultChemokinesCytokinesFemaleGraft SurvivalHumansMaleMiddle AgedViral LoadChemokinesCytokinesChemokinesCytokinesHIVHOPE ActInflammationKidneyOrgan donationOrgan transplantationTransplant

Identifiers

PMID40653253
PMCPMC12319627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.