Evidence map›Paper›PMID 40653145›Full record

ArticleProgress in neuro-psychopharmacology & biological psychiatry2025

Alcohol drinking is associated with greater calcium activity in mouse central amygdala dynorphin-expressing neurons.

Christina L Lebonville, Jennifer A Rinker, Krysten O'Hara, Christopher S McMahan, Michaela Hoffman, Howard C Becker, Patrick J Mulholland

Abstract read
In one paragraph

Article in Progress in neuro-psychopharmacology & biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Christina L LebonvilleDepartment of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, 173 Ashley Avenue, BSB 403 MSC 510, Charleston, SC 29425, USA; Department of Psychiatry & Behavioral Sciences, Charleston Alcohol Research Center, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, USA. Electronic address: lebonvil@musc.edu.
Jennifer A RinkerDepartment of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, 173 Ashley Avenue, BSB 403 MSC 510, Charleston, SC 29425, USA; Department of Psychiatry & Behavioral Sciences, Charleston Alcohol Research Center, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, USA. Electronic address: rinker@musc.edu.
Krysten O'HaraDepartment of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, 173 Ashley Avenue, BSB 403 MSC 510, Charleston, SC 29425, USA. Electronic address: oharak@musc.edu.
Christopher S McMahanSchool of Mathematical and Statistical Sciences, Clemson-MUSC Artificial Intelligence Hub, Clemson University, 220 Parkway Drive, Clemson, SC 29634-0975, USA. Electronic address: mcmaha2@clemson.edu.
Michaela HoffmanDepartment of Psychiatry & Behavioral Sciences, Charleston Alcohol Research Center, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, USA. Electronic address: hoffmami@musc.edu.
Howard C BeckerDepartment of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, 173 Ashley Avenue, BSB 403 MSC 510, Charleston, SC 29425, USA; Department of Psychiatry & Behavioral Sciences, Charleston Alcohol Research Center, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, USA; Ralph H. Johnson Department of Veterans Affairs Medical Center, 109 Bee Street, Charleston, SC 29401-5799, Charleston, SC 29425, USA. Electronic address: beckerh@musc.edu.
Patrick J MulhollandDepartment of Neuroscience, Charleston Alcohol Research Center, Medical University of South Carolina, 173 Ashley Avenue, BSB 403 MSC 510, Charleston, SC 29425, USA; Department of Psychiatry & Behavioral Sciences, Charleston Alcohol Research Center, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, USA. Electronic address: mulholl@musc.edu.

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Lisa M McTeague · 1996 to 2026
$46.8M
Vocational Training for Drug Dependent WomenP50DA016511 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2002 to 2017
$14.5M
Ethanol Dependence &Stress Effects on Ethanol DrinkingU01AA014095 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HOWARD C. BECKER · 2003 to 2026
$9.0M
Kv7 channels and heavy alcohol drinkingR01AA023288 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MULHOLLAND, PATRICK J. · 2014 to 2023
$3.4M
Stress and Ethanol Dependence: SK Channels and GlutamateU01AA020930 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MULHOLLAND, PATRICK J. · 2012 to 2021
$2.6M
Role of Oxytocin in a Mouse Model of PTSD-AUD ComorbidityR01AA026536 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BECKER, HOWARD C. · 2017 to 2021
$1.9M
Dependence-Induced Excessive Ethanol Consumption: Role of Corticostriatal Kv7 ChannelsK01AA025110 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RINKER, JENNIFER ANNE · 2017 to 2021
$930k
Superresolution Confocal Microscope for Biomedical ImagingS10OD021532 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MULHOLLAND, PATRICK J. · 2017 to 2017
$437k
Dynorphinergic projections from the insular cortex to the central amygdala: role in stress-enhanced alcohol drinking in dependenceF32AA029026 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEBONVILLE, CHRISTINA · 2020 to 2022
$201k
BLRD VA I01 BX000813NIAAA NIH HHS F32 AA029026NIAAA NIH HHS K01 AA025110NIAAA NIH HHS P50 AA010761NIAAA NIH HHS R01 AA023288NIAAA NIH HHS R01 AA026536NIAAA NIH HHS U01 AA014095NIAAA NIH HHS U01 AA020930NIDA NIH HHS P50 DA016511NIH HHS S10 OD021532
6 · The paper itself

Abstract

Alcohol use disorder (AUD) is a chronic disease that poses significant economic burden and health risks. It is pivotal to better understand brain mechanisms engaged by alcohol that promote misuse. The central amygdala (CeA) has emerged as a key mediator of excessive alcohol consumption in preclinical models. A dynorphin-expressing subpopulation within the CeA (CeA

Indexed as

Alcohol DrinkingCalciumCentral Amygdaloid NucleusDynorphinsNeuronsAnimalsEthanolFemaleMaleMiceMice, Inbred C57BLMice, TransgenicCalciumDynorphinsEthanolAlcoholAmygdalaAUDDrinkingDynorphinFiber photometryMixed modeling

Identifiers

PMID40653145
PMCPMC13022558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.