ArticleBritish journal of haematology2025
Late infections after high-dose therapy and autologous stem cell transplantation for lymphoma: A Danish population-based study.
Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Late infections after high-dose therapy and autologous stem cell transplantation for lymphoma: A Danish population-based study.British journal of haematology · 2025Article
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12 authors.
Funding
Abstract
Infectious complications after high-dose therapy and autologous stem cell transplantation (HDT-ASCT) for lymphoma are the leading cause of late non-relapse mortality. Characterizing the risk of infectious complications over time is important for rational follow-up and because alternatives to HDT-ASCT exist for some patients. This national cohort study investigated the risk of severe (defined by requiring hospitalization) late infections after 90 days among HDT-ASCT-treated patients with lymphoma in remission relative to the Danish background population (comparators) matched on age, sex and comorbidity score. Anti-cancer treatment after HDT-ASCT and death were competing events. This study included 781 patients and 3905 comparators. With a median follow-up of 7.7 years for patients, the incidence rate ratios of severe infections from 90 days until 2 years after HDT-ASCT was 8.43 (95% confidence interval (CI): 6.98-10.16) and the 2-year cumulative risk was 23.7% (95% CI: 20.7%-26.7%) for patients and 3.4% (95% CI: 2.9%-4.0%) for comparators. The risk of severe infections remained increased for up to 10 years after HDT-ASCT. Respiratory tract infections were the most frequent type, with a 2-year cumulative risk difference of 10.9% (95% CI: 8.6%-13.3%). Patients were more likely to be prescribed anti-infectives, including broad-spectrum antibiotics 5-10 years after HDT-ASCT.
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