Evidence map›Paper›PMID 40653069›Full record

ArticleEnvironmental research2025

Agricultural copper pesticide exposure and DNA methylation in Central Valley of California residents with and without Parkinson's disease.

Yufan Gong, Yu Yu, Keren Zhang, Irish Pearl Cambronero Del Rosario, Myles Cockburn, Laura K Thompson, Adrienne M Keener, Jeff Bronstein, Beate R Ritz, Kimberly C Paul

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In one paragraph

Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yufan GongDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Yu YuDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA; Center for Health Policy Research, University of California, Los Angeles, CA, USA.
Keren ZhangDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Irish Pearl Cambronero Del RosarioDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Myles CockburnDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, USA.
Laura K ThompsonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, USA.
Adrienne M KeenerDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Jeff BronsteinDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Beate R RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Environmental Health Science, Fielding School of Public Health, University of California, Los Angeles, CA, USA. Electronic address: britz@ucla.edu.
Kimberly C PaulDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Funding

PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Microbiome, Pesticides and Parkinsons in LatinosR01ES031106 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2020 to 2025
$3.8M
NIEHS NIH HHS R01 ES010544NIEHS NIH HHS R01 ES031106
6 · The paper itself

Abstract

backgroundCopper-induced oxidative damage and mitochondrial dysfunction may exacerbate Parkinson's disease (PD) pathology. DNA methylation (DNAm) can serve as a biological mediator of environmental exposures.

objectiveTo investigate the impact of chronic, long-term copper exposure on genome-wide DNA methylation patterns in the blood of PD cases and community controls.

methodsWe analyzed 806 blood samples (569 PD cases and 237 controls) from a population-based case-control study. Epigenome-wide association analysis (EWAS) was conducted to identify differentially methylated probes (DMPs) and regions (DMRs), adjusting for age, sex, European ancestry, smoking status, study wave, cell composition, and organophosphates (OP) exposure. In addition, overrepresentation analyses were conducted to identify enriched pathways and biological functions.

resultsWe identified 140 CpG sites and 40 genomic regions that were associated with copper pesticide exposure, including cg17591573 (r = -0.16, p = 8.84E-09) in the COL11A2 gene, cg11538176 in UBE3C (r = -0.18, p = 9.26E-09), cg11208322 in MAGI2 (r = -0.15, p = 1.00E-08) and a region located on chromosome 1 (bp start site 205818668; ends 205819609). DMP and DMR gene set enrichment analyses identified as the most enriched pathways Fc gamma R-mediated phagocytosis (p = 6.03E-05, FDR = 2.17E-02) and homophilic cell adhesion via plasma membrane adhesion molecules (p = 2.27E-07, FDR = 5.08E-03).

conclusionWe found evidence that long-term ambient exposure to copper pesticides resulted in differential DNA methylation in blood of PD patients and elderly controls. Chronic copper pesticide exposure may affect multiple pathways, specifically phagocytosis pathway, EGF receptor signaling pathway, and homophilic cell adhesion mechanisms that are relevant to neuroinflammation and neurodegeneration in PD.

Indexed as

CopperDNA MethylationEnvironmental ExposureEnvironmental PollutantsParkinson DiseasePesticidesAgedAgricultureCaliforniaCase-Control StudiesFemaleGenome-Wide Association StudyHumansMaleMiddle AgedCopperEnvironmental PollutantsPesticidesCopper pesticideDNA methylationParkinson's disease

Identifiers

PMID40653069
PMCPMC13159479

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.