ArticleJournal of affective disorders2025
Body mass index mediates the relationship between depression and triglyceride levels: Evidence from a large national cohort.
Article in Journal of affective disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mitochondrial dysfunction, a new marker warning of neuropsychiatric disorder risk: evidence from genetics and epidemiology.Annals of general psychiatry · 2025Article
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4 authors.
Funding
Abstract
backgroundMajor Depressive Disorder (MDD) is linked to adverse metabolic outcomes, including elevated triglycerides and body mass index (BMI). However, mechanisms underlying this relationship-and their variation by age or sex-remain unclear.
methodsUsing data from over 200,000 participants in the All of Us Research Program, we examined associations between MDD (defined by SNOMED-coded diagnoses), BMI, and lipid biomarkers (triglycerides, HDL, LDL). Causal mediation analyses tested whether BMI mediated the MDD-triglyceride relationship, adjusting for age, sex, and alcohol intake. Sex differences and age-stratified effects (ages 25, 45, 65) were also explored.
resultsIndividuals with MDD had higher BMI and triglyceride levels than those without (BMI SMD = 0.234; triglycerides SMD = 0.195; both p < 0.001). BMI significantly mediated the MDD-triglyceride association (ACME = 5.46, 95 % CI [2.95, 8.17], p < 0.001), accounting for 34.1 % of the total effect. The direct effect was not statistically significant (ADE = 10.55, p = 0.084). Mediation effects were consistent across sexes. Stronger mediation was observed at older ages (e.g., ACME = 6.07 at age 65, p < 0.001) but not at younger ages (e.g., ACME = 5.09 at age 25, p = 0.076). Multiple imputation analyses confirmed these findings (ACME = 3.71, 95 % CI [3.09, 4.33], p < 0.001; proportion mediated = 24.9 %). HDL and LDL levels differed modestly by MDD status.
conclusionsBMI partially mediates the relationship between MDD and triglycerides, particularly in older adults. These results support integrating metabolic risk management into mental health care.
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