ArticlePlant biotechnology journal2025
JA-responsive R2R3-type MYB transcription factor OsMYB4P confers broad-spectrum antiviral immunity in rice.
Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Review
- The Transcription Factor DPB Confers Antiviral Defence Against Potato Virus X by Modulating MYB-Dependent Signalling.Molecular plant pathology · 2026Article
- The Transcription Factor OsWRKY30 Regulates Rice Resistance to Southern Rice Black Streaked Dwarf Virus Disease.Rice (New York, N.Y.) · 2026Article
- Integrated transcriptomic analysis reveals transcriptional changes associated with begomovirus infection in the medicinal plantFrontiers in plant science · 2026Article
- Transcriptomic and metabolomic analyses reveal the molecular mechanisms by which long-day photoperiods promote flowering inFrontiers in plant science · 2025Article
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Authors and funding
14 authors.
Funding
Abstract
Jasmonic acid (JA) plays a critical role in antiviral defence in rice, where viral infection activates JA signalling by degrading Jasmonate ZIM domain (JAZ) proteins, thereby releasing transcription factors (TFs) to drive JA-mediated defence gene expression. While the JA-responsive TF OsMYC2 has been extensively studied in rice, the involvement of MYB TFs in JA signalling remains largely unexplored. In this study, we identified a novel JA-responsive R2R3-type MYB TF OsMYB4P. OsMYB4P functions as a transcriptional activator, activating the expression of the JA synthesis gene CM-LOX1, and positively regulating rice sensitivity to JA. Additionally, OsMYB4P interacts with OsJAZs and is subject to transcriptional inhibition by OsJAZs. Overexpression of OsMYB4P (OE-OsMYB4P) enhances rice resistance to viral infection, whereas knockout mutants (osmyb4p) exhibit increased susceptibility. Further studies revealed that viral proteins SP8 and P2, encoded by southern rice black-streaked dwarf virus (SRBSDV) and rice stripe virus (RSV), respectively, disrupt OsMYB4P self-interaction. This interference reduces OsMYB4P protein stability, transcriptional activation and DNA binding ability, thereby suppressing JA signalling and facilitating the viral infection. Overall, our findings demonstrate that the JA-responsive R2R3-type MYB TF OsMYB4P, as a direct target of JAZs, plays a key role in JA signalling and contributes to broad-spectrum antiviral defence in rice.
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