Evidence map›Paper›PMID 40652543›Full record

ArticleOral diseases2026

Infectious Complications in Patients Receiving Superselective Intra-Arterial Chemoradiotherapy for Oral Squamous Cell Carcinoma.

Hideaki Kato, Takashi Ohya, Toshiyuki Koizumi, Masaki Iida, Shoko Takano, Masaharu Hata, Hideaki Nakajima, Kenji Mitsudo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hideaki KatoInfection Prevention and Control Department, Yokohama City University Hospital, Yokohama, Japan.ORCID https://orcid.org/0000-0002-7853-5721
Takashi OhyaDepartment of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Toshiyuki KoizumiDepartment of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Masaki IidaDepartment of Oral and Maxillofacial Surgery, Shonan-Kamakura General Hospital, Kamakura, Japan.
Shoko TakanoDepartment of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Masaharu HataDepartment of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Hideaki NakajimaDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Kenji MitsudoDepartment of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSuperselective intra-arterial chemoradiotherapy (IACRT) is a radical treatment performed to preserve function in patients with oral cancer. However, the characteristics of infectious complications in this patient population and the prognostic impact remain unclear.

methodsWe retrospectively reviewed 245 consecutive patients who underwent IACRT from 2008 to 2016. The characteristics of those who developed infectious complications during IACRT were compared with those who did not.

resultsOne hundred eighty-four infectious complications occurred during IACRT in 133/245 (54%) patients, including intra-arterial catheter site infection (19.0%, 2.7/1000 catheter-days), central line- and peripheral catheter-associated bloodstream infection (8.7%), febrile neutropenia (16.3%), pneumonia (8.7%), Clostridioides difficile infection (8.7%) and fever of unknown origin (26.6%). Multivariate regression analysis revealed that central venous catheter placement (adjusted odds ratio: 1.42) and Grade 3/4 neutropenia (adjusted odds ratio: 1.23) were significantly associated with infectious complications. Patients with infectious complications during IACRT had a worse prognosis than those without, with 5-year overall survival rates of 66.2% and 79.4%, respectively.

conclusionsInfectious complications during IACRT interrupt the course of cancer treatment, worsening prognosis. Thus, close monitoring and infection prevention measures are suggested to improve prognosis in patients with oral cancer undergoing IACRT.

Indexed as

Carcinoma, Squamous CellCatheter-Related InfectionsChemoradiotherapyMouth NeoplasmsAgedAged, 80 and overFebrile NeutropeniaFemaleHumansInfusions, Intra-ArterialMaleMiddle AgedPneumoniaPrognosisRetrospective StudiesSurvival Ratechemoradiotherapydevice‐associated infectionfebrile neutropeniainfectious complicationsintra‐arterial catheteroral cancersquamous cell carcinoma

Identifiers

PMID40652543
PMCPMC13365018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.