ArticleThe FEBS journal2025
Ras pathways help buffer biological timekeeping against metabolic perturbations.
Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Circadian clocks need to be buffered against changes in conditions that could affect their rate and disrupt their timekeeping function. The circadian period of the fungus Neurospora is compensated across a range of nutritional conditions. Several gene products are implicated in the mechanism, but a complete picture is lacking. Sárkány et al. report that a Ras pathway linked to cAMP is required to maintain a constant period under low glucose conditions. They extend this work to a human cell line showing similar effects of the homologous Ras pathway, pointing toward potential conservation of compensation pathways across eukaryotes.
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