Evidence map›Paper›PMID 40652409›Full record

ArticleImmunotherapy2025

Nivolumab induced discolouration of the tongue: a case report.

Elif Değirmenci Aktaş, Dilek Yildirim

Abstract readCase Reports
In one paragraph

Article in Immunotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elif Değirmenci AktaşDepartment of Oncology Clinics, Koç University Hospital, Istanbul, Turkey.ORCID 0000-0001-6115-0035
Dilek YildirimDepartment of Nursing, Faculty of Health Sciences, Istanbul Aydin University, Istanbul, Turkey.ORCID 0000-0002-6228-0007

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, immune checkpoint inhibitors are used in the treatment of ovarian cancer. Immunotherapy agents occasionally cause the development of skin reactions characterized by mild erythematous and maculopapular rashes, usually involving the trunk and extremities of the body, which may occasionally present with pruritus. It is especially seen in the use of anti-PD-1 (nivolumab and pembrolizumab) treatment agents. In this case report, we present a patient who developed discoloration of the tongue toxicity after nivolumab treatment in ovarian cancer patients. Discoloration of the tongue, which is one of the rare side effects of immunotherapy, and factors that may be associated with it are discussed in this case.

Indexed as

Antineoplastic Agents, ImmunologicalImmune Checkpoint InhibitorsNivolumabOvarian NeoplasmsTongueFemaleHumansMiddle AgedAntineoplastic Agents, ImmunologicalImmune Checkpoint InhibitorsNivolumabImmonotherapymucosal pigmentationoral adverse eventovarian cancertreatment side effects

Identifiers

PMID40652409
PMCPMC12355674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.