ArticleAnnals of medicine2025
The association between cerebral small vessel disease and unfavorable hematoma morphology in primary intracerebral hemorrhage.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
objectiveTo study the association between cerebral small vessel diseases (CSVD) and unfavorable hematoma morphology in primary intracerebral hemorrhage (ICH).
methodsPatients with primary ICH who were admitted to West China Hospital of Sichuan University from March 2012 to January 2021 were consecutively included. The unfavorable hematoma morphology included any hypodensity, any irregularity, black hole, blend sign, Barras shape score ≥3, Barras density score ≥3, immature hematoma and combined Barras total score (CBTS) ≥4. The combined hematoma morphology score (CHMS) was evaluated by allocating 1 point for the presence of each of the mentioned unfavorable hematoma morphology. Multivariable binary logistic and ordinal regressions, together with unsupervised machine learning, were used to determine the association between CSVD and unfavorable hematoma morphology features.
resultsUnivariable analysis showed that older age and hypertension were associated with white matter hyperintensities (WMH) presence. Regarding hematoma morphology, Barras density score ≥3, CBTS ≥4 and higher CHMS were associated with WMH absence (all
conclusionsLower CSVD burden might be associated with higher incidence of unfavorable hematoma morphology features, such as CTBS ≥4 and higher CHMS.
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